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Diagnostic Value of Multiple Tumor Markers for Patients with Esophageal Carcinoma
BACKGROUND: Various studies assessing the diagnostic value of serum tumor markers in patients with esophageal cancer remain controversial. This study aims to comprehensively and quantitatively summarize the potential diagnostic value of 5 serum tumour markers in esophageal cancer. METHODS: We system...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333286/ https://www.ncbi.nlm.nih.gov/pubmed/25693076 http://dx.doi.org/10.1371/journal.pone.0116951 |
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author | Zhang, Jun Zhu, Zhenli Liu, Yan Jin, Xueyuan Xu, Zhiwei Yu, Qiuyan Li, Ke |
author_facet | Zhang, Jun Zhu, Zhenli Liu, Yan Jin, Xueyuan Xu, Zhiwei Yu, Qiuyan Li, Ke |
author_sort | Zhang, Jun |
collection | PubMed |
description | BACKGROUND: Various studies assessing the diagnostic value of serum tumor markers in patients with esophageal cancer remain controversial. This study aims to comprehensively and quantitatively summarize the potential diagnostic value of 5 serum tumour markers in esophageal cancer. METHODS: We systematically searched PubMed, Embase, Chinese National Knowledge Infrastructure (CNKI) and Chinese Biomedical Database (CBM), through February 28, 2013, without language restriction. Studies were assessed for quality using QUADAS (quality assessment of studies of diagnostic accuracy). The positive likelihood ratio (PLR) and negative likelihood ratio (NLR) were pooled separately and compared with overall accuracy measures using diagnostic odds ratios (DORs) and symmetric summary receiver operating characteristic (SROC) curves. RESULTS: Of 4391 studies initially identified, 44 eligible studies including five tumor markers met the inclusion criteria for the meta-analysis, while meta-analysis could not be conducted for 12 other tumor markers. Approximately 79.55% (35/44) of the included studies were of relatively high quality (QUADAS score≥7). The summary estimates of the positive likelihood ratio (PLR), negative likelihood ratio (NLR) and diagnostic odds ratio (DOR) for diagnosing EC were as follows: CEA, 5.94/0.76/9.26; Cyfra21-1, 12.110.59/22.27; p53 antibody, 6.71/0.75/9.60; SCC-Ag, 7.66/0.68/12.41; and VEGF-C, 0.74/0.37/8.12. The estimated summary receiver operating characteristic curves showed that the performance of all five tumor markers was reasonable. CONCLUSIONS: The current evidence suggests that CEA, Cyfra21-1, p53, SCC-Ag and VEGF-C have a potential diagnostic value for esophageal carcinoma. |
format | Online Article Text |
id | pubmed-4333286 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-43332862015-02-24 Diagnostic Value of Multiple Tumor Markers for Patients with Esophageal Carcinoma Zhang, Jun Zhu, Zhenli Liu, Yan Jin, Xueyuan Xu, Zhiwei Yu, Qiuyan Li, Ke PLoS One Research Article BACKGROUND: Various studies assessing the diagnostic value of serum tumor markers in patients with esophageal cancer remain controversial. This study aims to comprehensively and quantitatively summarize the potential diagnostic value of 5 serum tumour markers in esophageal cancer. METHODS: We systematically searched PubMed, Embase, Chinese National Knowledge Infrastructure (CNKI) and Chinese Biomedical Database (CBM), through February 28, 2013, without language restriction. Studies were assessed for quality using QUADAS (quality assessment of studies of diagnostic accuracy). The positive likelihood ratio (PLR) and negative likelihood ratio (NLR) were pooled separately and compared with overall accuracy measures using diagnostic odds ratios (DORs) and symmetric summary receiver operating characteristic (SROC) curves. RESULTS: Of 4391 studies initially identified, 44 eligible studies including five tumor markers met the inclusion criteria for the meta-analysis, while meta-analysis could not be conducted for 12 other tumor markers. Approximately 79.55% (35/44) of the included studies were of relatively high quality (QUADAS score≥7). The summary estimates of the positive likelihood ratio (PLR), negative likelihood ratio (NLR) and diagnostic odds ratio (DOR) for diagnosing EC were as follows: CEA, 5.94/0.76/9.26; Cyfra21-1, 12.110.59/22.27; p53 antibody, 6.71/0.75/9.60; SCC-Ag, 7.66/0.68/12.41; and VEGF-C, 0.74/0.37/8.12. The estimated summary receiver operating characteristic curves showed that the performance of all five tumor markers was reasonable. CONCLUSIONS: The current evidence suggests that CEA, Cyfra21-1, p53, SCC-Ag and VEGF-C have a potential diagnostic value for esophageal carcinoma. Public Library of Science 2015-02-18 /pmc/articles/PMC4333286/ /pubmed/25693076 http://dx.doi.org/10.1371/journal.pone.0116951 Text en © 2015 Zhang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Zhang, Jun Zhu, Zhenli Liu, Yan Jin, Xueyuan Xu, Zhiwei Yu, Qiuyan Li, Ke Diagnostic Value of Multiple Tumor Markers for Patients with Esophageal Carcinoma |
title | Diagnostic Value of Multiple Tumor Markers for Patients with Esophageal Carcinoma |
title_full | Diagnostic Value of Multiple Tumor Markers for Patients with Esophageal Carcinoma |
title_fullStr | Diagnostic Value of Multiple Tumor Markers for Patients with Esophageal Carcinoma |
title_full_unstemmed | Diagnostic Value of Multiple Tumor Markers for Patients with Esophageal Carcinoma |
title_short | Diagnostic Value of Multiple Tumor Markers for Patients with Esophageal Carcinoma |
title_sort | diagnostic value of multiple tumor markers for patients with esophageal carcinoma |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333286/ https://www.ncbi.nlm.nih.gov/pubmed/25693076 http://dx.doi.org/10.1371/journal.pone.0116951 |
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