Cargando…

Role of COX-2/mPGES-1/Prostaglandin E2 Cascade in Kidney Injury

COX-2/mPGES-1/PGE2 cascade plays critical roles in modulating many physiological and pathological actions in different organs. In the kidney, this cascade is of high importance in regulating fluid metabolism, blood pressure, and renal hemodynamics. Under some disease conditions, this cascade display...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jia, Zhanjun, Zhang, Yue, Ding, Guixia, Heiney, Kristina Marie, Huang, Songming, Zhang, Aihua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2015
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333324/ https://www.ncbi.nlm.nih.gov/pubmed/25729216 http://dx.doi.org/10.1155/2015/147894

Ejemplares similares

COX-2/mPGES-1/PGE(2) cascade activation mediates uric acid-induced mesangial cell proliferation
por: Li, Shuzhen, et al.
Publicado: (2016)

Mitochondrial oxidative stress activates COX-2/mPGES-1/PGE2 cascade induced by albumin in renal proximal tubular cells
por: Zhuang, Yibo, et al.
Publicado: (2018)

Pulmonary and Cardiorenal Cyclooxygenase-1 (COX-1), -2 (COX-2), and Microsomal Prostaglandin E Synthase-1 (mPGES-1) and -2 (mPGES-2) Expression in a Hypertension Model
por: Radi, Zaher A., et al.
Publicado: (2007)

Nitrooleic Acid Protects against Cisplatin Nephropathy: Role of COX-2/mPGES-1/PGE(2) Cascade
por: Wang, Haiping, et al.
Publicado: (2015)

Simultaneous expression of COX-2 and mPGES-1 in mouse gastrointestinal hamartomas
por: Takeda, H, et al.
Publicado: (2004)

Mechanistic definition of the cardiovascular mPGES-1/COX-2/ADMA axis
por: Kirkby, Nicholas S, et al.
Publicado: (2019)

The role of mPGES-1 for prostaglandin E(2 )production in primary human synovial cells
por: Crofford, L, et al.
Publicado: (2003)

mPGES-1 and prostaglandin E(2): vital role in inflammation, hypoxic response, and survival
por: Siljehav, Veronica, et al.
Publicado: (2012)

COX-2 but Not mPGES-1 Contributes to Renal PGE2 Induction and Diabetic Proteinuria in Mice with Type-1 Diabetes
por: Jia, Zhanjun, et al.
Publicado: (2014)

Inflammatory Resolution Triggers a Prolonged Phase of Immune Suppression through COX-1/mPGES-1-Derived Prostaglandin E(2)
por: Newson, Justine, et al.
Publicado: (2017)

Prostaglandin E2 synthesis in cartilage explants under compression: mPGES-1 is a mechanosensitive gene
por: Gosset, Marjolaine, et al.
Publicado: (2006)

Poly(I:C) increases the expression of mPGES-1 and COX-2 in rat primary microglia
por: de Oliveira, Antonio Carlos Pinheiro, et al.
Publicado: (2016)

Mycobacterium tuberculosis-Induced Upregulation of the COX-2/mPGES-1 Pathway in Human Macrophages Is Abrogated by Sulfasalazine
por: Wang, Wenfei, et al.
Publicado: (2022)

Pharmacological inhibition of Akt and downstream pathways modulates the expression of COX-2 and mPGES-1 in activated microglia
por: de Oliveira, Antonio CP, et al.
Publicado: (2012)

Pharmacophore Modeling and Virtual Screening for Novel Acidic Inhibitors of Microsomal Prostaglandin E(2) Synthase-1 (mPGES-1)
por: Waltenberger, Birgit, et al.
Publicado: (2011)

Targeting mPGES-2 to protect against acute kidney injury via inhibition of ferroptosis dependent on p53
por: Zhong, Dandan, et al.
Publicado: (2023)

Analgesic effects of a highly selective mPGES-1 inhibitor
por: Stewart, Madeline J., et al.
Publicado: (2023)

Inhibition of mPGES-1 or COX-2 Results in Different Proteomic and Lipidomic Profiles in A549 Lung Cancer Cells
por: Bergqvist, Filip, et al.
Publicado: (2019)

Invalidation of Microsomal Prostaglandin E Synthase-1 (mPGES-1) Reduces Diet-Induced Low-Grade Inflammation and Adiposity
por: Pierre, Clément, et al.
Publicado: (2018)

PPARγ Agonist Rosiglitazone Suppresses Renal mPGES-1/PGE2 Pathway in db/db Mice
por: Sun, Ying, et al.
Publicado: (2013)

Targeting mPGES-1 as a New Strategy against Neuroblastoma
por: Comunanza, Valentina
Publicado: (2018)

The cyclooxygenase-1/mPGES-1/endothelial prostaglandin EP4 receptor pathway constrains myocardial ischemia-reperfusion injury
por: Zhu, Liyuan, et al.
Publicado: (2019)

LDL-Dependent Regulation of TNFα/PGE(2) Induced COX-2/mPGES-1 Expression in Human Macrophage Cell Lines
por: Neuschäfer-Rube, Frank, et al.
Publicado: (2023)

Aggravation of acute kidney injury by mPGES-2 down regulation is associated with autophagy inhibition and enhanced apoptosis
por: Li, Ting, et al.
Publicado: (2017)

Transcriptional regulation of the mPGES-1 gene in primary cultured articular chondrocytes
por: Bausero, P, et al.
Publicado: (2004)

mPGES-1 null mice are resistant to bleomycin-induced skin fibrosis
por: McCann, Matthew R, et al.
Publicado: (2011)

Enhanced mPGES-1 Contributes to PD-Related Peritoneal Fibrosis via Activation of the NLRP3 Inflammasome
por: Luo, Qimei, et al.
Publicado: (2021)

Augmented liver inflammation in a microsomal prostaglandin E synthase 1 (mPGES-1)-deficient diet-induced mouse NASH model
por: Henkel, Janin, et al.
Publicado: (2018)

Antipyretic activity of Caesalpinia digyna (Rottl.) leaves extract along with phytoconstituent’s binding affinity to COX-1, COX-2, and mPGES-1 receptors: In vivo and in silico approaches
por: Emon, Nazim Uddin, et al.
Publicado: (2021)

Regulation of calcitonin gene-related peptide expression through the COX-2/mPGES-1/PGE2 pathway in the infrapatellar fat pad in knee osteoarthritis
por: Aikawa, Jun, et al.
Publicado: (2018)

Effect of Proton Pump Inhibitor Therapy on NOX5, mPGES1 and iNOS expression in Barrett’s Esophagus
por: Li, Dan, et al.
Publicado: (2019)

Correction: mPGES-1 null mice are resistant to bleomycin-induced skin fibrosis
por: McCann, Matthew R, et al.
Publicado: (2011)

Consequences of altered eicosanoid patterns for nociceptive processing in mPGES-1-deficient mice
por: Brenneis, Christian, et al.
Publicado: (2008)

Arzanol, a Potent mPGES-1 Inhibitor: Novel Anti-Inflammatory Agent
por: Kothavade, Pankaj S., et al.
Publicado: (2013)

Identification of 2-(thiophen-2-yl)acetic Acid-Based Lead Compound for mPGES-1 Inhibition
por: Di Micco, Simone, et al.
Publicado: (2021)

Author Correction: Aggravation of acute kidney injury by mPGES-2 down regulation is associated with autophagy inhibition and enhanced apoptosis
por: Li, Ting, et al.
Publicado: (2018)

Prostaglandins in the pathogenesis of kidney diseases
por: Li, Yuanyuan, et al.
Publicado: (2018)

Microsomal prostaglandin E synthase-1 (mPGES-1) promotes hepatocarcinogenesis through activation of a novel EGR1/β-catenin signaling axis
por: Lu, Dongdong, et al.
Publicado: (2011)

In Silico, In Vitro and In Vivo Analysis of Tanshinone IIA and Cryptotanshinone from Salvia miltiorrhiza as Modulators of Cyclooxygenase-2/mPGES-1/Endothelial Prostaglandin EP3 Pathway
por: Saviano, Anella, et al.
Publicado: (2022)

DREAM-in-CDM Approach and Identification of a New Generation of Anti-inflammatory Drugs Targeting mPGES-1
por: Zhou, Shuo, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_5s4btikuhl6mge5sn2v83o5tl0