An improved kilogram-scale preparation of atorvastatin calcium

BACKGROUND: If literature protocols are followed, conversion of an advanced ketal ester intermediate (available in kilogram quantities via a published Paal-Knorr synthesis) to cholesterol-lowering drug atorvastatin calcium is hampered by several process issues, particularly at the final stage where...

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Detalles Bibliográficos
Autores principales: Novozhilov, Yuri V, Dorogov, Mikhail V, Blumina, Maria V, Smirnov, Alexey V, Krasavin, Mikhail
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2015
Materias:
Preliminary Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333361/
https://www.ncbi.nlm.nih.gov/pubmed/25705254
http://dx.doi.org/10.1186/s13065-015-0082-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333361/
https://www.ncbi.nlm.nih.gov/pubmed/25705254
http://dx.doi.org/10.1186/s13065-015-0082-7

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