Short loop-targeting oligoribonucleotides antagonize Lin28 and enable pre-let-7 processing and suppression of cell growth in let-7-deficient cancer cells

MicroRNAs (miRNAs) originate from stem-loop-containing precursors (pre-miRNAs, pri-miRNAs) and mature by means of the Drosha and Dicer endonucleases and their associated factors. The let-7 miRNAs have prominent roles in developmental differentiation and in regulating cell proliferation. In cancer, t...

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Detalles Bibliográficos
Autores principales: Roos, Martina, Rebhan, Mario A. E., Lucic, Matije, Pavlicek, David, Pradere, Ugo, Towbin, Harry, Civenni, Gianluca, Catapano, Carlo V., Hall, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333367/
https://www.ncbi.nlm.nih.gov/pubmed/25378324
http://dx.doi.org/10.1093/nar/gku1090

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