High-resolution HDX-MS reveals distinct mechanisms of RNA recognition and activation by RIG-I and MDA5

RIG-I and MDA5 are the major intracellular immune receptors that recognize viral RNA species and undergo a series of conformational transitions leading to the activation of the interferon-mediated antiviral response. However, to date, full-length RLRs have resisted crystallographic efforts and a mol...

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Detalles Bibliográficos
Autores principales: Zheng, Jie, Yong, Hui Yee, Panutdaporn, Nantika, Liu, Chuanfa, Tang, Kai, Luo, Dahai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333383/
https://www.ncbi.nlm.nih.gov/pubmed/25539915
http://dx.doi.org/10.1093/nar/gku1329

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333383/
https://www.ncbi.nlm.nih.gov/pubmed/25539915
http://dx.doi.org/10.1093/nar/gku1329

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