Creating a monomeric endonuclease TALE-I-SceI with high specificity and low genotoxicity in human cells

To correct a DNA mutation in the human genome for gene therapy, homology-directed repair (HDR) needs to be specific and have the lowest off-target effects to protect the human genome from deleterious mutations. Zinc finger nucleases, transcription activator-like effector nuclease (TALEN) and CRISPR-...

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Detalles Bibliográficos
Autores principales: Lin, Jianfei, Chen, He, Luo, Ling, Lai, Yongrong, Xie, Wei, Kee, Kehkooi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333390/
https://www.ncbi.nlm.nih.gov/pubmed/25541197
http://dx.doi.org/10.1093/nar/gku1339

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333390/
https://www.ncbi.nlm.nih.gov/pubmed/25541197
http://dx.doi.org/10.1093/nar/gku1339

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