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Creating a monomeric endonuclease TALE-I-SceI with high specificity and low genotoxicity in human cells
To correct a DNA mutation in the human genome for gene therapy, homology-directed repair (HDR) needs to be specific and have the lowest off-target effects to protect the human genome from deleterious mutations. Zinc finger nucleases, transcription activator-like effector nuclease (TALEN) and CRISPR-...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333390/ https://www.ncbi.nlm.nih.gov/pubmed/25541197 http://dx.doi.org/10.1093/nar/gku1339 |