The prion protein is critical for DNA repair and cell survival after genotoxic stress

The prion protein (PrP) is highly conserved and ubiquitously expressed, suggesting that it plays an important physiological function. However, despite decades of investigation, this role remains elusive. Here, by using animal and cellular models, we unveil a key role of PrP in the DNA damage respons...

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Detalles Bibliográficos
Autores principales: Bravard, Anne, Auvré, Frédéric, Fantini, Damiano, Bernardino-Sgherri, Jacqueline, Sissoëff, Ludmilla, Daynac, Mathieu, Xu, Zhou, Etienne, Olivier, Dehen, Capucine, Comoy, Emmanuel, Boussin, François D., Tell, Gianluca, Deslys, Jean-Philippe, Radicella, J. Pablo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333392/
https://www.ncbi.nlm.nih.gov/pubmed/25539913
http://dx.doi.org/10.1093/nar/gku1342

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333392/
https://www.ncbi.nlm.nih.gov/pubmed/25539913
http://dx.doi.org/10.1093/nar/gku1342

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