Recognition of duplex RNA by the deaminase domain of the RNA editing enzyme ADAR2

Adenosine deaminases acting on RNA (ADARs) hydrolytically deaminate adenosines (A) in a wide variety of duplex RNAs and misregulation of editing is correlated with human disease. However, our understanding of reaction selectivity is limited. ADARs are modular enzymes with multiple double-stranded RN...

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Detalles Bibliográficos
Autores principales: Phelps, Kelly J., Tran, Kiet, Eifler, Tristan, Erickson, Anna I., Fisher, Andrew J., Beal, Peter A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333395/
https://www.ncbi.nlm.nih.gov/pubmed/25564529
http://dx.doi.org/10.1093/nar/gku1345

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333395/
https://www.ncbi.nlm.nih.gov/pubmed/25564529
http://dx.doi.org/10.1093/nar/gku1345

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