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Recognition of duplex RNA by the deaminase domain of the RNA editing enzyme ADAR2

Adenosine deaminases acting on RNA (ADARs) hydrolytically deaminate adenosines (A) in a wide variety of duplex RNAs and misregulation of editing is correlated with human disease. However, our understanding of reaction selectivity is limited. ADARs are modular enzymes with multiple double-stranded RN...

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Detalles Bibliográficos
Autores principales:	Phelps, Kelly J., Tran, Kiet, Eifler, Tristan, Erickson, Anna I., Fisher, Andrew J., Beal, Peter A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333395/ https://www.ncbi.nlm.nih.gov/pubmed/25564529 http://dx.doi.org/10.1093/nar/gku1345

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