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DNA binding by FOXP3 domain-swapped dimer suggests mechanisms of long-range chromosomal interactions

FOXP3 is a lineage-specific transcription factor that is required for regulatory T cell development and function. In this study, we determined the crystal structure of the FOXP3 forkhead domain bound to DNA. The structure reveals that FOXP3 can form a stable domain-swapped dimer to bridge DNA in the...

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Detalles Bibliográficos
Autores principales:	Chen, Yongheng, Chen, Chunxia, Zhang, Zhe, Liu, Chun-Chi, Johnson, Matthew E., Espinoza, Celso A., Edsall, Lee E., Ren, Bing, Zhou, Xianghong Jasmine, Grant, Struan F.A., Wells, Andrew D., Chen, Lin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333414/ https://www.ncbi.nlm.nih.gov/pubmed/25567984 http://dx.doi.org/10.1093/nar/gku1373

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