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Neddylation inhibits CtIP-mediated resection and regulates DNA double strand break repair pathway choice

DNA double strand breaks are the most cytotoxic lesions that can occur on the DNA. They can be repaired by different mechanisms and optimal survival requires a tight control between them. Here we uncover protein deneddylation as a major controller of repair pathway choice. Neddylation inhibition cha...

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Detalles Bibliográficos
Autores principales:	Jimeno, Sonia, Fernández-Ávila, María Jesús, Cruz-García, Andrés, Cepeda-García, Cristina, Gómez-Cabello, Daniel, Huertas, Pablo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333419/ https://www.ncbi.nlm.nih.gov/pubmed/25567988 http://dx.doi.org/10.1093/nar/gku1384

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