REV7 is essential for DNA damage tolerance via two REV3L binding sites in mammalian DNA polymerase ζ

DNA polymerase zeta (pol ζ) is exceptionally important for controlling mutagenesis and genetic instability. REV3L comprises the catalytic subunit, while REV7 (MAD2L2) is considered an accessory subunit. However, it has not been established that the role of REV7 in DNA damage tolerance is necessarily...

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Detalles Bibliográficos
Autores principales: Tomida, Junya, Takata, Kei-ichi, Lange, Sabine S., Schibler, Andria C., Yousefzadeh, Matthew J., Bhetawal, Sarita, Dent, Sharon Y.R., Wood, Richard D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333420/
https://www.ncbi.nlm.nih.gov/pubmed/25567983
http://dx.doi.org/10.1093/nar/gku1385

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