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Transcriptional inhibition and mutagenesis induced by N-nitroso compound-derived carboxymethylated thymidine adducts in DNA

N-nitroso compounds represent a common type of environmental and endogenous DNA-damaging agents. After metabolic activation, many N-nitroso compounds are converted into a diazoacetate intermediate that can react with nucleobases to give carboxymethylated DNA adducts such as N3-carboxymethylthymidine...

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Detalles Bibliográficos
Autores principales:	You, Changjun, Wang, Jianshuang, Dai, Xiaoxia, Wang, Yinsheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333421/ https://www.ncbi.nlm.nih.gov/pubmed/25572317 http://dx.doi.org/10.1093/nar/gku1391

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