BRCA1 haplotype and clinical benefit of trabectedin in soft-tissue sarcoma patients

BACKGROUND: This study aimed to determine whether the BRCA1 haplotype was associated with trabectedin efficacy in soft-tissue sarcoma (STS) patients. METHODS: We analysed BRCA1 single-nucleotide polymorphisms (SNPs) in tumour specimens from 135 advanced STS patients enrolled in published phase 2 tri...

Descripción completa

Detalles Bibliográficos
Autores principales: Laroche-Clary, A, Chaire, V, Le Morvan, V, Neuville, A, Bertucci, F, Salas, S, Sanfilippo, R, Pourquier, P, Italiano, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333490/
https://www.ncbi.nlm.nih.gov/pubmed/25602962
http://dx.doi.org/10.1038/bjc.2014.624

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333490/
https://www.ncbi.nlm.nih.gov/pubmed/25602962
http://dx.doi.org/10.1038/bjc.2014.624

Ejemplares similares