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UDP-Glucuronosyltransferase 1A Determinates Intracellular Accumulation and Anti-Cancer Effect of β-Lapachone in Human Colon Cancer Cells

β-lapachone (β-lap), an NAD(P)H:quinone oxidoreductase 1 (NQO1) targeting antitumor drug candidate in phase II clinical trials, is metabolically eliminated via NQO1 mediated quinone reduction and subsequent UDP-glucuronosyltransferases (UGTs) catalyzed glucuronidation. This study intends to explore...

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Detalles Bibliográficos
Autores principales:	Liu, Huiying, Li, Qingran, Cheng, Xuefang, Wang, Hong, Wang, Guangji, Hao, Haiping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333567/ https://www.ncbi.nlm.nih.gov/pubmed/25692465 http://dx.doi.org/10.1371/journal.pone.0117051

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