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Ulcer healing activity of Mumijo aqueous extract against acetic acid induced gastric ulcer in rats

OBJECTIVE: Gastric ulcer is an important clinical problem, chiefly due to extensive use of some drugs. The aim was to assess the activity of Mumijo extract (which is used in traditional medicine) against acetic acid induced gastric ulcer in rats. MATERIALS AND METHODS: The aqueous extract of Mumijo...

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Autores principales: Shahrokhi, Nader, Keshavarzi, Zakieh, Khaksari, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333629/
https://www.ncbi.nlm.nih.gov/pubmed/25709338
http://dx.doi.org/10.4103/0975-7406.148739
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author Shahrokhi, Nader
Keshavarzi, Zakieh
Khaksari, Mohammad
author_facet Shahrokhi, Nader
Keshavarzi, Zakieh
Khaksari, Mohammad
author_sort Shahrokhi, Nader
collection PubMed
description OBJECTIVE: Gastric ulcer is an important clinical problem, chiefly due to extensive use of some drugs. The aim was to assess the activity of Mumijo extract (which is used in traditional medicine) against acetic acid induced gastric ulcer in rats. MATERIALS AND METHODS: The aqueous extract of Mumijo was prepared. Animals were randomly (n = 10) divided into four groups: Control, sham-operated group (received 0.2 ml of acetic acid to induce gastric ulcer), Mumijo (100 mg/kg/daily) were given for 4 days postacetic acid administration, and ranitidine group (20 mg/kg). The assessed parameters were pH and pepsin levels (by Anson method) of gastric contents and gastric histopathology. Ranitidine was used as reference anti-ulcer drug. RESULTS: The extract (100 mg/kg/daily, p.o.) inhibited acid acetic-induced gastric ulceration by elevating its pH versus sham group (P < 0.01) and decreasing the pepsin levels compared to standard drug, ranitidine (P < 0.05). The histopathology data showed that the treatment with Mumijo extract had a significant protection against all mucosal damages. CONCLUSION: Mumijo extract has potent antiulcer activity. Its anti-ulcer property probably acts via a reduction in gastric acid secretion and pepsin levels. The obtained results support the use of this herbal material in folk medicine.
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spelling pubmed-43336292015-02-23 Ulcer healing activity of Mumijo aqueous extract against acetic acid induced gastric ulcer in rats Shahrokhi, Nader Keshavarzi, Zakieh Khaksari, Mohammad J Pharm Bioallied Sci Original Article OBJECTIVE: Gastric ulcer is an important clinical problem, chiefly due to extensive use of some drugs. The aim was to assess the activity of Mumijo extract (which is used in traditional medicine) against acetic acid induced gastric ulcer in rats. MATERIALS AND METHODS: The aqueous extract of Mumijo was prepared. Animals were randomly (n = 10) divided into four groups: Control, sham-operated group (received 0.2 ml of acetic acid to induce gastric ulcer), Mumijo (100 mg/kg/daily) were given for 4 days postacetic acid administration, and ranitidine group (20 mg/kg). The assessed parameters were pH and pepsin levels (by Anson method) of gastric contents and gastric histopathology. Ranitidine was used as reference anti-ulcer drug. RESULTS: The extract (100 mg/kg/daily, p.o.) inhibited acid acetic-induced gastric ulceration by elevating its pH versus sham group (P < 0.01) and decreasing the pepsin levels compared to standard drug, ranitidine (P < 0.05). The histopathology data showed that the treatment with Mumijo extract had a significant protection against all mucosal damages. CONCLUSION: Mumijo extract has potent antiulcer activity. Its anti-ulcer property probably acts via a reduction in gastric acid secretion and pepsin levels. The obtained results support the use of this herbal material in folk medicine. Medknow Publications & Media Pvt Ltd 2015 /pmc/articles/PMC4333629/ /pubmed/25709338 http://dx.doi.org/10.4103/0975-7406.148739 Text en Copyright: © Journal of Pharmacy and Bioallied Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Shahrokhi, Nader
Keshavarzi, Zakieh
Khaksari, Mohammad
Ulcer healing activity of Mumijo aqueous extract against acetic acid induced gastric ulcer in rats
title Ulcer healing activity of Mumijo aqueous extract against acetic acid induced gastric ulcer in rats
title_full Ulcer healing activity of Mumijo aqueous extract against acetic acid induced gastric ulcer in rats
title_fullStr Ulcer healing activity of Mumijo aqueous extract against acetic acid induced gastric ulcer in rats
title_full_unstemmed Ulcer healing activity of Mumijo aqueous extract against acetic acid induced gastric ulcer in rats
title_short Ulcer healing activity of Mumijo aqueous extract against acetic acid induced gastric ulcer in rats
title_sort ulcer healing activity of mumijo aqueous extract against acetic acid induced gastric ulcer in rats
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333629/
https://www.ncbi.nlm.nih.gov/pubmed/25709338
http://dx.doi.org/10.4103/0975-7406.148739
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