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Synthesis and antimicrobial activity of some new diphenylamine derivatives
In search of new leads toward potent antimicrobial agent, an array of novel derivatives of 2-hydrazinyl–N-N, diphenyl acetamide has been synthesized from the chloroacetylation reaction of diphenylamine (DPA). For this, a series of DPA derivatives were prepared by replacing chlorine with hydrazine hy...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333634/ https://www.ncbi.nlm.nih.gov/pubmed/25709343 http://dx.doi.org/10.4103/0975-7406.148774 |
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author | Kumar, Arvind Mishra, Arun K. |
author_facet | Kumar, Arvind Mishra, Arun K. |
author_sort | Kumar, Arvind |
collection | PubMed |
description | In search of new leads toward potent antimicrobial agent, an array of novel derivatives of 2-hydrazinyl–N-N, diphenyl acetamide has been synthesized from the chloroacetylation reaction of diphenylamine (DPA). For this, a series of DPA derivatives were prepared by replacing chlorine with hydrazine hydrate in alcoholic medium and 2-hydrazino-N, N-diphenylacetamide was synthesized. The 2-hydrazino-N, N-diphenylacetamide was further subjected to reaction with various aromatic aldehydes in presence of glacial acetic acid in methanol. The synthesized compounds were characterized by their IR, 1HNMR spectral data and elemental analysis. The compounds were screened for antibacterial and antifungal activity by cup plate method. 2-(2-Benzylidenehydrazinyl)-N, N-diphenylacetamide (A1); 2-(2-(3-methylbenzylidene) hydrazinyl)-N, N-diphenyl-acetamide (A5) and 2-(2-(2-nitrobenzylidine) hydrazinyl)-N, N-diphenyl-acetamide compounds (A7) showed significant antimicrobial as well as antifungal activity. Diphenylamine compounds may be explored as potent antimicrobial and antifungal compounds. |
format | Online Article Text |
id | pubmed-4333634 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-43336342015-02-23 Synthesis and antimicrobial activity of some new diphenylamine derivatives Kumar, Arvind Mishra, Arun K. J Pharm Bioallied Sci Short Communication In search of new leads toward potent antimicrobial agent, an array of novel derivatives of 2-hydrazinyl–N-N, diphenyl acetamide has been synthesized from the chloroacetylation reaction of diphenylamine (DPA). For this, a series of DPA derivatives were prepared by replacing chlorine with hydrazine hydrate in alcoholic medium and 2-hydrazino-N, N-diphenylacetamide was synthesized. The 2-hydrazino-N, N-diphenylacetamide was further subjected to reaction with various aromatic aldehydes in presence of glacial acetic acid in methanol. The synthesized compounds were characterized by their IR, 1HNMR spectral data and elemental analysis. The compounds were screened for antibacterial and antifungal activity by cup plate method. 2-(2-Benzylidenehydrazinyl)-N, N-diphenylacetamide (A1); 2-(2-(3-methylbenzylidene) hydrazinyl)-N, N-diphenyl-acetamide (A5) and 2-(2-(2-nitrobenzylidine) hydrazinyl)-N, N-diphenyl-acetamide compounds (A7) showed significant antimicrobial as well as antifungal activity. Diphenylamine compounds may be explored as potent antimicrobial and antifungal compounds. Medknow Publications & Media Pvt Ltd 2015 /pmc/articles/PMC4333634/ /pubmed/25709343 http://dx.doi.org/10.4103/0975-7406.148774 Text en Copyright: © Journal of Pharmacy and Bioallied Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Communication Kumar, Arvind Mishra, Arun K. Synthesis and antimicrobial activity of some new diphenylamine derivatives |
title | Synthesis and antimicrobial activity of some new diphenylamine derivatives |
title_full | Synthesis and antimicrobial activity of some new diphenylamine derivatives |
title_fullStr | Synthesis and antimicrobial activity of some new diphenylamine derivatives |
title_full_unstemmed | Synthesis and antimicrobial activity of some new diphenylamine derivatives |
title_short | Synthesis and antimicrobial activity of some new diphenylamine derivatives |
title_sort | synthesis and antimicrobial activity of some new diphenylamine derivatives |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333634/ https://www.ncbi.nlm.nih.gov/pubmed/25709343 http://dx.doi.org/10.4103/0975-7406.148774 |
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