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(18)F-FDG PET-CT for Surveillance of Brazilian Patients with Li-Fraumeni Syndrome
Purpose: To evaluate the effectiveness of (18)F-Fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG-PET/CT) for detecting early cancer in carriers of germline TP53 mutation, the genetic defect underlying Li-Fraumeni and related syndromes, which predisposes to many forms of...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333808/ https://www.ncbi.nlm.nih.gov/pubmed/25745605 http://dx.doi.org/10.3389/fonc.2015.00038 |
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author | Nogueira, Sonia Tereza Santos Lima, Eduardo Nóbrega Pereira Nóbrega, Amanda França Torres, Ivone Do Carmo Gonçalves Cavicchioli, Marcelo Hainaut, Pierre Achatz, Maria Isabel Waddington |
author_facet | Nogueira, Sonia Tereza Santos Lima, Eduardo Nóbrega Pereira Nóbrega, Amanda França Torres, Ivone Do Carmo Gonçalves Cavicchioli, Marcelo Hainaut, Pierre Achatz, Maria Isabel Waddington |
author_sort | Nogueira, Sonia Tereza Santos |
collection | PubMed |
description | Purpose: To evaluate the effectiveness of (18)F-Fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG-PET/CT) for detecting early cancer in carriers of germline TP53 mutation, the genetic defect underlying Li-Fraumeni and related syndromes, which predisposes to many forms of cancer throughout life. Patients and methods: A total of 30 adult patients from six families with germline TP53 mutations were recruited. These patients did not have a diagnosis of cancer in the 24 months preceding the study. Anomalous concentrations from whole-body (18)F-FDG-PET/CT were assessed by two independent experts. Suspicious lesions were excised and subjected to pathological examination. Results: A total of 6/30 patients showed abnormal (18)F-FDG-concentration. Confirmation studies revealed three cases of cancer, including one lung cancer, one ovarian cancer, and one disseminated breast cancer. Three patients had non-malignant lesions (one Bartholin’s cyst and two cases of reactive lymph nodes). Conclusion: (18)F-FDG-PET/CT is effective in detecting cancer in subjects who are asymptomatic according to current screening guidelines. These results further suggest that (18)F-FDG-PET/CT is an appropriate method for surveillance of cancer risk in TP53 mutation carriers. |
format | Online Article Text |
id | pubmed-4333808 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-43338082015-03-05 (18)F-FDG PET-CT for Surveillance of Brazilian Patients with Li-Fraumeni Syndrome Nogueira, Sonia Tereza Santos Lima, Eduardo Nóbrega Pereira Nóbrega, Amanda França Torres, Ivone Do Carmo Gonçalves Cavicchioli, Marcelo Hainaut, Pierre Achatz, Maria Isabel Waddington Front Oncol Oncology Purpose: To evaluate the effectiveness of (18)F-Fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG-PET/CT) for detecting early cancer in carriers of germline TP53 mutation, the genetic defect underlying Li-Fraumeni and related syndromes, which predisposes to many forms of cancer throughout life. Patients and methods: A total of 30 adult patients from six families with germline TP53 mutations were recruited. These patients did not have a diagnosis of cancer in the 24 months preceding the study. Anomalous concentrations from whole-body (18)F-FDG-PET/CT were assessed by two independent experts. Suspicious lesions were excised and subjected to pathological examination. Results: A total of 6/30 patients showed abnormal (18)F-FDG-concentration. Confirmation studies revealed three cases of cancer, including one lung cancer, one ovarian cancer, and one disseminated breast cancer. Three patients had non-malignant lesions (one Bartholin’s cyst and two cases of reactive lymph nodes). Conclusion: (18)F-FDG-PET/CT is effective in detecting cancer in subjects who are asymptomatic according to current screening guidelines. These results further suggest that (18)F-FDG-PET/CT is an appropriate method for surveillance of cancer risk in TP53 mutation carriers. Frontiers Media S.A. 2015-02-19 /pmc/articles/PMC4333808/ /pubmed/25745605 http://dx.doi.org/10.3389/fonc.2015.00038 Text en Copyright © 2015 Nogueira, Lima, Nóbrega, Torres, Cavicchioli, Hainaut and Achatz. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Nogueira, Sonia Tereza Santos Lima, Eduardo Nóbrega Pereira Nóbrega, Amanda França Torres, Ivone Do Carmo Gonçalves Cavicchioli, Marcelo Hainaut, Pierre Achatz, Maria Isabel Waddington (18)F-FDG PET-CT for Surveillance of Brazilian Patients with Li-Fraumeni Syndrome |
title | (18)F-FDG PET-CT for Surveillance of Brazilian Patients with Li-Fraumeni Syndrome |
title_full | (18)F-FDG PET-CT for Surveillance of Brazilian Patients with Li-Fraumeni Syndrome |
title_fullStr | (18)F-FDG PET-CT for Surveillance of Brazilian Patients with Li-Fraumeni Syndrome |
title_full_unstemmed | (18)F-FDG PET-CT for Surveillance of Brazilian Patients with Li-Fraumeni Syndrome |
title_short | (18)F-FDG PET-CT for Surveillance of Brazilian Patients with Li-Fraumeni Syndrome |
title_sort | (18)f-fdg pet-ct for surveillance of brazilian patients with li-fraumeni syndrome |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333808/ https://www.ncbi.nlm.nih.gov/pubmed/25745605 http://dx.doi.org/10.3389/fonc.2015.00038 |
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