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Natural Killer Cells and Their Activation Status in Normal Pregnancy

Increased peripheral blood-activated NK cell counts are associated with increased risk of miscarriage and failed in vitro fertilization treatment. However, assessment of activated peripheral NK cells in normal and pathological pregnancies beyond implantation and early miscarriage has not been descri...

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Autores principales: Mosimann, Beatrice, Wagner, Marion, Shehata, Hassan, Poon, Leona C. Y., Ford, Brian, Nicolaides, Kypros H., Bansal, Amolak S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334074/
https://www.ncbi.nlm.nih.gov/pubmed/25763390
http://dx.doi.org/10.1155/2013/906813
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author Mosimann, Beatrice
Wagner, Marion
Shehata, Hassan
Poon, Leona C. Y.
Ford, Brian
Nicolaides, Kypros H.
Bansal, Amolak S.
author_facet Mosimann, Beatrice
Wagner, Marion
Shehata, Hassan
Poon, Leona C. Y.
Ford, Brian
Nicolaides, Kypros H.
Bansal, Amolak S.
author_sort Mosimann, Beatrice
collection PubMed
description Increased peripheral blood-activated NK cell counts are associated with increased risk of miscarriage and failed in vitro fertilization treatment. However, assessment of activated peripheral NK cells in normal and pathological pregnancies beyond implantation and early miscarriage has not been described. Total CD69 expressing NK cells counts were measured by flow cytometry in healthy women with singleton pregnancies, including 45 at 11(+6)–13(+6) weeks' gestation, 46 at 20(+0)–22(+4) weeks, and 42 at 31(+6)–33(+5) weeks. The number of peripheral blood NK cells decreased, whereas the percentage of activated CD69 expressing NK cells increased from the first to the third trimester of pregnancy. This study shows the course of peripheral blood NK cells and activated CD69 expressing NK cells in uncomplicated nulliparous singleton pregnancies. This is a first step in understanding their implication in pathological pregnancies.
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spelling pubmed-43340742015-03-11 Natural Killer Cells and Their Activation Status in Normal Pregnancy Mosimann, Beatrice Wagner, Marion Shehata, Hassan Poon, Leona C. Y. Ford, Brian Nicolaides, Kypros H. Bansal, Amolak S. Int J Reprod Med Clinical Study Increased peripheral blood-activated NK cell counts are associated with increased risk of miscarriage and failed in vitro fertilization treatment. However, assessment of activated peripheral NK cells in normal and pathological pregnancies beyond implantation and early miscarriage has not been described. Total CD69 expressing NK cells counts were measured by flow cytometry in healthy women with singleton pregnancies, including 45 at 11(+6)–13(+6) weeks' gestation, 46 at 20(+0)–22(+4) weeks, and 42 at 31(+6)–33(+5) weeks. The number of peripheral blood NK cells decreased, whereas the percentage of activated CD69 expressing NK cells increased from the first to the third trimester of pregnancy. This study shows the course of peripheral blood NK cells and activated CD69 expressing NK cells in uncomplicated nulliparous singleton pregnancies. This is a first step in understanding their implication in pathological pregnancies. Hindawi Publishing Corporation 2013 2013-03-27 /pmc/articles/PMC4334074/ /pubmed/25763390 http://dx.doi.org/10.1155/2013/906813 Text en Copyright © 2013 Beatrice Mosimann et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Mosimann, Beatrice
Wagner, Marion
Shehata, Hassan
Poon, Leona C. Y.
Ford, Brian
Nicolaides, Kypros H.
Bansal, Amolak S.
Natural Killer Cells and Their Activation Status in Normal Pregnancy
title Natural Killer Cells and Their Activation Status in Normal Pregnancy
title_full Natural Killer Cells and Their Activation Status in Normal Pregnancy
title_fullStr Natural Killer Cells and Their Activation Status in Normal Pregnancy
title_full_unstemmed Natural Killer Cells and Their Activation Status in Normal Pregnancy
title_short Natural Killer Cells and Their Activation Status in Normal Pregnancy
title_sort natural killer cells and their activation status in normal pregnancy
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334074/
https://www.ncbi.nlm.nih.gov/pubmed/25763390
http://dx.doi.org/10.1155/2013/906813
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