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Mechanistic insights into xanthine oxidoreductase from development studies of candidate drugs to treat hyperuricemia and gout
Xanthine oxidoreductase (XOR), which is widely distributed from humans to bacteria, has a key role in purine catabolism, catalyzing two steps of sequential hydroxylation from hypoxanthine to xanthine and from xanthine to urate at its molybdenum cofactor (Moco). Human XOR is considered to be a target...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Springer Berlin Heidelberg
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334109/ https://www.ncbi.nlm.nih.gov/pubmed/25501928 http://dx.doi.org/10.1007/s00775-014-1210-x |