Inducamides A–C, Chlorinated Alkaloids from an RNA Polymerase Mutant Strain of Streptomyces sp.

[Image: see text] Inducamides A–C (1–3), three new chlorinated alkaloids featuring an amide skeleton generated by a tryptophan fragment and a 6-methylsalicylic acid unit, were isolated from a chemically induced mutant strain of Streptomyces sp. with the inducamides only being produced in the mutant...

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Autores principales: Fu, Peng, Jamison, Matthew, La, Scott, MacMillan, John B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334230/
https://www.ncbi.nlm.nih.gov/pubmed/25338006
http://dx.doi.org/10.1021/ol502731p
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author Fu, Peng
Jamison, Matthew
La, Scott
MacMillan, John B.
author_facet Fu, Peng
Jamison, Matthew
La, Scott
MacMillan, John B.
author_sort Fu, Peng
collection PubMed
description [Image: see text] Inducamides A–C (1–3), three new chlorinated alkaloids featuring an amide skeleton generated by a tryptophan fragment and a 6-methylsalicylic acid unit, were isolated from a chemically induced mutant strain of Streptomyces sp. with the inducamides only being produced in the mutant strain. Their structures, including stereochemistry, were determined by spectroscopic analysis, Marfey’s method, and CD spectroscopy.
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spelling pubmed-43342302015-10-22 Inducamides A–C, Chlorinated Alkaloids from an RNA Polymerase Mutant Strain of Streptomyces sp. Fu, Peng Jamison, Matthew La, Scott MacMillan, John B. Org Lett [Image: see text] Inducamides A–C (1–3), three new chlorinated alkaloids featuring an amide skeleton generated by a tryptophan fragment and a 6-methylsalicylic acid unit, were isolated from a chemically induced mutant strain of Streptomyces sp. with the inducamides only being produced in the mutant strain. Their structures, including stereochemistry, were determined by spectroscopic analysis, Marfey’s method, and CD spectroscopy. American Chemical Society 2014-10-22 2014-11-07 /pmc/articles/PMC4334230/ /pubmed/25338006 http://dx.doi.org/10.1021/ol502731p Text en Copyright © 2014 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Fu, Peng
Jamison, Matthew
La, Scott
MacMillan, John B.
Inducamides A–C, Chlorinated Alkaloids from an RNA Polymerase Mutant Strain of Streptomyces sp.
title Inducamides A–C, Chlorinated Alkaloids from an RNA Polymerase Mutant Strain of Streptomyces sp.
title_full Inducamides A–C, Chlorinated Alkaloids from an RNA Polymerase Mutant Strain of Streptomyces sp.
title_fullStr Inducamides A–C, Chlorinated Alkaloids from an RNA Polymerase Mutant Strain of Streptomyces sp.
title_full_unstemmed Inducamides A–C, Chlorinated Alkaloids from an RNA Polymerase Mutant Strain of Streptomyces sp.
title_short Inducamides A–C, Chlorinated Alkaloids from an RNA Polymerase Mutant Strain of Streptomyces sp.
title_sort inducamides a–c, chlorinated alkaloids from an rna polymerase mutant strain of streptomyces sp.
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334230/
https://www.ncbi.nlm.nih.gov/pubmed/25338006
http://dx.doi.org/10.1021/ol502731p
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