The G-protein Alpha Subunit Gsα Is A Tumor Suppressor In Sonic Hedgehog-driven Medulloblastoma

Medulloblastoma, the most common malignant childhood brain tumor, exhibits distinct molecular subtypes and cellular origins. Genetic alterations driving medulloblastoma initiation and progression remain poorly understood. Herein, we identify GNAS, encoding the G-protein Gsα, as a potent tumor suppre...

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Detalles Bibliográficos
Autores principales: He, Xuelian, Zhang, Liguo, Chen, Ying, Remke, Marc, Shih, David, Lu, Fanghui, Wang, Haibo, Deng, Yaqi, Yu, Yang, Xia, Yong, Wu, Xiaochong, Ramaswamy, Vijay, Hu, Tom, Wang, Fan, Zhou, Wenhao, Burns, Dennis K., Kim, Se Hoon, Kool, Marcel, Pfister, Stefan M., Weinstein, Lee S., Pomeroy, Scott L., Gilbertson, Richard J., Rubin, Joshua B., Hou, Yiping, Wechsler-Reya, Robert, Taylor, Michael D., Lu, Q. Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334261/
https://www.ncbi.nlm.nih.gov/pubmed/25150496
http://dx.doi.org/10.1038/nm.3666

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