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Hybrid Nanotrimers for Dual T(1) and T(2)-Weighted Magnetic Resonance Imaging

[Image: see text] Development of multifunctional nanoparticle-based probes for dual T(1)- and T(2)-weighted magnetic resonance imaging (MRI) could allow us to image and diagnose the tumors or other abnormalities in an exceptionally accurate and reliable manner. In this study, by fusing distinct nano...

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Autores principales: Cheng, Kai, Yang, Meng, Zhang, Ruiping, Qin, Chunxia, Su, Xinhui, Cheng, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334264/
https://www.ncbi.nlm.nih.gov/pubmed/25283972
http://dx.doi.org/10.1021/nn500188y
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author Cheng, Kai
Yang, Meng
Zhang, Ruiping
Qin, Chunxia
Su, Xinhui
Cheng, Zhen
author_facet Cheng, Kai
Yang, Meng
Zhang, Ruiping
Qin, Chunxia
Su, Xinhui
Cheng, Zhen
author_sort Cheng, Kai
collection PubMed
description [Image: see text] Development of multifunctional nanoparticle-based probes for dual T(1)- and T(2)-weighted magnetic resonance imaging (MRI) could allow us to image and diagnose the tumors or other abnormalities in an exceptionally accurate and reliable manner. In this study, by fusing distinct nanocrystals via solid-state interfaces, we built hybrid heteronanostructures to combine both T(1) and T(2)- weighted contrast agents together for MRI with high accuracy and reliability. The resultant hybrid heterotrimers showed high stability in physiological conditions and could induce both simultaneous positive and negative contrast enhancements in MR images. Small animal positron emission tomography imaging study revealed that the hybrid heterostructures displayed favorable biodistribution and were suitable for in vivo imaging. Their potential as dual contrast agents for T(1) and T(2)-weighted MRI was further demonstrated by in vitro and in vivo imaging and relaxivity measurements.
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spelling pubmed-43342642015-10-04 Hybrid Nanotrimers for Dual T(1) and T(2)-Weighted Magnetic Resonance Imaging Cheng, Kai Yang, Meng Zhang, Ruiping Qin, Chunxia Su, Xinhui Cheng, Zhen ACS Nano [Image: see text] Development of multifunctional nanoparticle-based probes for dual T(1)- and T(2)-weighted magnetic resonance imaging (MRI) could allow us to image and diagnose the tumors or other abnormalities in an exceptionally accurate and reliable manner. In this study, by fusing distinct nanocrystals via solid-state interfaces, we built hybrid heteronanostructures to combine both T(1) and T(2)- weighted contrast agents together for MRI with high accuracy and reliability. The resultant hybrid heterotrimers showed high stability in physiological conditions and could induce both simultaneous positive and negative contrast enhancements in MR images. Small animal positron emission tomography imaging study revealed that the hybrid heterostructures displayed favorable biodistribution and were suitable for in vivo imaging. Their potential as dual contrast agents for T(1) and T(2)-weighted MRI was further demonstrated by in vitro and in vivo imaging and relaxivity measurements. American Chemical Society 2014-10-04 2014-10-28 /pmc/articles/PMC4334264/ /pubmed/25283972 http://dx.doi.org/10.1021/nn500188y Text en Copyright © 2014 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Cheng, Kai
Yang, Meng
Zhang, Ruiping
Qin, Chunxia
Su, Xinhui
Cheng, Zhen
Hybrid Nanotrimers for Dual T(1) and T(2)-Weighted Magnetic Resonance Imaging
title Hybrid Nanotrimers for Dual T(1) and T(2)-Weighted Magnetic Resonance Imaging
title_full Hybrid Nanotrimers for Dual T(1) and T(2)-Weighted Magnetic Resonance Imaging
title_fullStr Hybrid Nanotrimers for Dual T(1) and T(2)-Weighted Magnetic Resonance Imaging
title_full_unstemmed Hybrid Nanotrimers for Dual T(1) and T(2)-Weighted Magnetic Resonance Imaging
title_short Hybrid Nanotrimers for Dual T(1) and T(2)-Weighted Magnetic Resonance Imaging
title_sort hybrid nanotrimers for dual t(1) and t(2)-weighted magnetic resonance imaging
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334264/
https://www.ncbi.nlm.nih.gov/pubmed/25283972
http://dx.doi.org/10.1021/nn500188y
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