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Forced oscillations and respiratory system modeling in adults with cystic fibrosis
BACKGROUND: The Forced Oscillation Technique (FOT) has the potential to increase our knowledge about the biomechanical changes that occur in Cystic Fibrosis (CF). Thus, the aims of this study were to investigate changes in the resistive and reactive properties of the respiratory systems of adults wi...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334397/ https://www.ncbi.nlm.nih.gov/pubmed/25889005 http://dx.doi.org/10.1186/s12938-015-0007-7 |
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author | Lima, Adma N Faria, Alvaro C D Lopes, Agnaldo J Jansen, José M Melo, Pedro L |
author_facet | Lima, Adma N Faria, Alvaro C D Lopes, Agnaldo J Jansen, José M Melo, Pedro L |
author_sort | Lima, Adma N |
collection | PubMed |
description | BACKGROUND: The Forced Oscillation Technique (FOT) has the potential to increase our knowledge about the biomechanical changes that occur in Cystic Fibrosis (CF). Thus, the aims of this study were to investigate changes in the resistive and reactive properties of the respiratory systems of adults with CF. METHODS: The study was conducted in a group of 27 adults with CF over 18 years old and a control group of 23 healthy individuals, both of which were assessed by the FOT, plethysmography and spirometry. An equivalent electrical circuit model was also used to quantify biomechanical changes and to gain physiological insight. RESULTS AND DISCUSSION: The CF adults presented an increased total respiratory resistance (p < 0.0001), increased resistance curve slope (p < 0.0006) and reduced dynamic compliance (p < 0.0001). In close agreement with the physiology of CF, the model analysis showed increased peripheral resistance (p < 0.0005) and reduced compliance (p < 0.0004) and inertance (p < 0.005). Significant reasonable to good correlations were observed between the resistive parameters and spirometric and plethysmographic indexes. Similar associations were observed for the reactive parameters. Peripheral resistance, obtained by the model analysis, presented reasonable (R = 0.35) to good (R = 0.64) relationships with plethysmographic parameters. CONCLUSIONS: The FOT adequately assessed the biomechanical changes associated with CF. The model used provides sensitive indicators of lung function and has the capacity to differentiate between obstructed and non-obstructed airway conditions. The FOT shows great potential for the clinical assessment of respiratory mechanics in adults with CF. |
format | Online Article Text |
id | pubmed-4334397 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-43343972015-02-20 Forced oscillations and respiratory system modeling in adults with cystic fibrosis Lima, Adma N Faria, Alvaro C D Lopes, Agnaldo J Jansen, José M Melo, Pedro L Biomed Eng Online Research BACKGROUND: The Forced Oscillation Technique (FOT) has the potential to increase our knowledge about the biomechanical changes that occur in Cystic Fibrosis (CF). Thus, the aims of this study were to investigate changes in the resistive and reactive properties of the respiratory systems of adults with CF. METHODS: The study was conducted in a group of 27 adults with CF over 18 years old and a control group of 23 healthy individuals, both of which were assessed by the FOT, plethysmography and spirometry. An equivalent electrical circuit model was also used to quantify biomechanical changes and to gain physiological insight. RESULTS AND DISCUSSION: The CF adults presented an increased total respiratory resistance (p < 0.0001), increased resistance curve slope (p < 0.0006) and reduced dynamic compliance (p < 0.0001). In close agreement with the physiology of CF, the model analysis showed increased peripheral resistance (p < 0.0005) and reduced compliance (p < 0.0004) and inertance (p < 0.005). Significant reasonable to good correlations were observed between the resistive parameters and spirometric and plethysmographic indexes. Similar associations were observed for the reactive parameters. Peripheral resistance, obtained by the model analysis, presented reasonable (R = 0.35) to good (R = 0.64) relationships with plethysmographic parameters. CONCLUSIONS: The FOT adequately assessed the biomechanical changes associated with CF. The model used provides sensitive indicators of lung function and has the capacity to differentiate between obstructed and non-obstructed airway conditions. The FOT shows great potential for the clinical assessment of respiratory mechanics in adults with CF. BioMed Central 2015-02-13 /pmc/articles/PMC4334397/ /pubmed/25889005 http://dx.doi.org/10.1186/s12938-015-0007-7 Text en © Lima et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Lima, Adma N Faria, Alvaro C D Lopes, Agnaldo J Jansen, José M Melo, Pedro L Forced oscillations and respiratory system modeling in adults with cystic fibrosis |
title | Forced oscillations and respiratory system modeling in adults with cystic fibrosis |
title_full | Forced oscillations and respiratory system modeling in adults with cystic fibrosis |
title_fullStr | Forced oscillations and respiratory system modeling in adults with cystic fibrosis |
title_full_unstemmed | Forced oscillations and respiratory system modeling in adults with cystic fibrosis |
title_short | Forced oscillations and respiratory system modeling in adults with cystic fibrosis |
title_sort | forced oscillations and respiratory system modeling in adults with cystic fibrosis |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334397/ https://www.ncbi.nlm.nih.gov/pubmed/25889005 http://dx.doi.org/10.1186/s12938-015-0007-7 |
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