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Rapid reprogramming of epigenetic and transcriptional profiles in mammalian culture systems

BACKGROUND: The DNA methylation profiles of mammalian cell lines differ from those of the primary tissues from which they were derived, exhibiting increasing divergence from the in vivo methylation profile with extended time in culture. Few studies have directly examined the initial epigenetic and t...

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Detalles Bibliográficos
Autores principales:	Nestor, Colm E, Ottaviano, Raffaele, Reinhardt, Diana, Cruickshanks, Hazel A, Mjoseng, Heidi K, McPherson, Rhoanne C, Lentini, Antonio, Thomson, John P, Dunican, Donncha S, Pennings, Sari, Anderton, Stephen M, Benson, Mikael, Meehan, Richard R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334405/ https://www.ncbi.nlm.nih.gov/pubmed/25648825 http://dx.doi.org/10.1186/s13059-014-0576-y

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