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Giant Congenital Melanocytic Nevi and Neurocutaneous Melanosis
Introduction. The major medical concern with giant congenital melanocytic nevi CMN is high risk of developing cutaneous melanoma, leptomeningeal melanoma, and neurocutaneous melanocytosis. Case Report. A 30-year-old woman with a giant congenital melanocytic nevus covering nearly the entire right tho...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334432/ https://www.ncbi.nlm.nih.gov/pubmed/25722729 http://dx.doi.org/10.1155/2015/545603 |
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author | Araújo, Catarina Resende, Cristina Pardal, Francisco Brito, Celeste |
author_facet | Araújo, Catarina Resende, Cristina Pardal, Francisco Brito, Celeste |
author_sort | Araújo, Catarina |
collection | PubMed |
description | Introduction. The major medical concern with giant congenital melanocytic nevi CMN is high risk of developing cutaneous melanoma, leptomeningeal melanoma, and neurocutaneous melanocytosis. Case Report. A 30-year-old woman with a giant congenital melanocytic nevus covering nearly the entire right thoracodorsal region and multiple disseminated melanocytic nevi presented with neurological symptoms. Cerebral magnetic resonance imaging revealed a large expansive lesion in the left frontal region. Postsurgically pathological diagnosis revealed characteristics of melanoma. Immunohistochemical examination showed S100(+), HMB45(+), MelanA(+), and MiTF(+). She received radiotherapy with temozolomide followed by two more chemotherapy cycles with temozolomide. She followed a rapidly progressive course, reflecting widespread leptomeningeal infiltration, and she died of multiorgan failure seven months after diagnosis of cerebral melanoma. Discussion. This patient was diagnosed as having a neurocutaneous melanosis with malignant widespread leptomeningeal infiltration. Diffuse spinal involvement is unusual and is described in only another patient. |
format | Online Article Text |
id | pubmed-4334432 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-43344322015-02-26 Giant Congenital Melanocytic Nevi and Neurocutaneous Melanosis Araújo, Catarina Resende, Cristina Pardal, Francisco Brito, Celeste Case Rep Med Case Report Introduction. The major medical concern with giant congenital melanocytic nevi CMN is high risk of developing cutaneous melanoma, leptomeningeal melanoma, and neurocutaneous melanocytosis. Case Report. A 30-year-old woman with a giant congenital melanocytic nevus covering nearly the entire right thoracodorsal region and multiple disseminated melanocytic nevi presented with neurological symptoms. Cerebral magnetic resonance imaging revealed a large expansive lesion in the left frontal region. Postsurgically pathological diagnosis revealed characteristics of melanoma. Immunohistochemical examination showed S100(+), HMB45(+), MelanA(+), and MiTF(+). She received radiotherapy with temozolomide followed by two more chemotherapy cycles with temozolomide. She followed a rapidly progressive course, reflecting widespread leptomeningeal infiltration, and she died of multiorgan failure seven months after diagnosis of cerebral melanoma. Discussion. This patient was diagnosed as having a neurocutaneous melanosis with malignant widespread leptomeningeal infiltration. Diffuse spinal involvement is unusual and is described in only another patient. Hindawi Publishing Corporation 2015 2015-02-04 /pmc/articles/PMC4334432/ /pubmed/25722729 http://dx.doi.org/10.1155/2015/545603 Text en Copyright © 2015 Catarina Araújo et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Araújo, Catarina Resende, Cristina Pardal, Francisco Brito, Celeste Giant Congenital Melanocytic Nevi and Neurocutaneous Melanosis |
title | Giant Congenital Melanocytic Nevi and Neurocutaneous Melanosis |
title_full | Giant Congenital Melanocytic Nevi and Neurocutaneous Melanosis |
title_fullStr | Giant Congenital Melanocytic Nevi and Neurocutaneous Melanosis |
title_full_unstemmed | Giant Congenital Melanocytic Nevi and Neurocutaneous Melanosis |
title_short | Giant Congenital Melanocytic Nevi and Neurocutaneous Melanosis |
title_sort | giant congenital melanocytic nevi and neurocutaneous melanosis |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334432/ https://www.ncbi.nlm.nih.gov/pubmed/25722729 http://dx.doi.org/10.1155/2015/545603 |
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