Muscle IGF-1-Induced Skeletal Muscle Hypertrophy Evokes Higher Insulin Sensitivity and Carbohydrate Use as Preferential Energy Substrate

We characterized the metabolic profile of transgenic mice exhibiting enhanced muscle mass driven by increased mIGF-1 expression (MLC/mIGF-1). As expected, 6-month-old MLC/mIGF-1 mice were heavier than age-matched wild type (WT) mice (37.4 ± 0.3 versus 31.8 ± 0.6 g, resp.). MLC/mIGF-1 mice had higher...

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Detalles Bibliográficos
Autores principales: Christoffolete, Marcelo Augusto, Silva, William Jose, Ramos, Gracielle Vieira, Bento, Mirella Ribeiro, Costa, Monique Oliveira, Ribeiro, Miriam Oliveira, Okamoto, Maristela Mitiko, Lohmann, Tania Helena, Machado, Ubiratan Fabres, Musarò, Antonio, Moriscot, Anselmo Sigari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334619/
https://www.ncbi.nlm.nih.gov/pubmed/25722973
http://dx.doi.org/10.1155/2015/282984

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