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Altered Intra- and Interregional Synchronization in Resting-State Cerebral Networks Associated with Chronic Tinnitus
Objective. Subjective tinnitus is hypothesized to arise from aberrant neural activity; however, its neural bases are poorly understood. To identify aberrant neural networks involved in chronic tinnitus, we compared the resting-state functional magnetic resonance imaging (fMRI) patterns of tinnitus p...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334979/ https://www.ncbi.nlm.nih.gov/pubmed/25734018 http://dx.doi.org/10.1155/2015/475382 |
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author | Chen, Yu-Chen Zhang, Jian Li, Xiao-Wei Xia, Wenqing Feng, Xu Qian, Cheng Yang, Xiang-Yu Lu, Chun-Qiang Wang, Jian Salvi, Richard Teng, Gao-Jun |
author_facet | Chen, Yu-Chen Zhang, Jian Li, Xiao-Wei Xia, Wenqing Feng, Xu Qian, Cheng Yang, Xiang-Yu Lu, Chun-Qiang Wang, Jian Salvi, Richard Teng, Gao-Jun |
author_sort | Chen, Yu-Chen |
collection | PubMed |
description | Objective. Subjective tinnitus is hypothesized to arise from aberrant neural activity; however, its neural bases are poorly understood. To identify aberrant neural networks involved in chronic tinnitus, we compared the resting-state functional magnetic resonance imaging (fMRI) patterns of tinnitus patients and healthy controls. Materials and Methods. Resting-state fMRI measurements were obtained from a group of chronic tinnitus patients (n = 29) with normal hearing and well-matched healthy controls (n = 30). Regional homogeneity (ReHo) analysis and functional connectivity analysis were used to identify abnormal brain activity; these abnormalities were compared to tinnitus distress. Results. Relative to healthy controls, tinnitus patients had significant greater ReHo values in several brain regions including the bilateral anterior insula (AI), left inferior frontal gyrus, and right supramarginal gyrus. Furthermore, the left AI showed enhanced functional connectivity with the left middle frontal gyrus (MFG), while the right AI had enhanced functional connectivity with the right MFG; these measures were positively correlated with Tinnitus Handicap Questionnaires (r = 0.459, P = 0.012 and r = 0.479, P = 0.009, resp.). Conclusions. Chronic tinnitus patients showed abnormal intra- and interregional synchronization in several resting-state cerebral networks; these abnormalities were correlated with clinical tinnitus distress. These results suggest that tinnitus distress is exacerbated by attention networks that focus on internally generated phantom sounds. |
format | Online Article Text |
id | pubmed-4334979 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-43349792015-03-02 Altered Intra- and Interregional Synchronization in Resting-State Cerebral Networks Associated with Chronic Tinnitus Chen, Yu-Chen Zhang, Jian Li, Xiao-Wei Xia, Wenqing Feng, Xu Qian, Cheng Yang, Xiang-Yu Lu, Chun-Qiang Wang, Jian Salvi, Richard Teng, Gao-Jun Neural Plast Research Article Objective. Subjective tinnitus is hypothesized to arise from aberrant neural activity; however, its neural bases are poorly understood. To identify aberrant neural networks involved in chronic tinnitus, we compared the resting-state functional magnetic resonance imaging (fMRI) patterns of tinnitus patients and healthy controls. Materials and Methods. Resting-state fMRI measurements were obtained from a group of chronic tinnitus patients (n = 29) with normal hearing and well-matched healthy controls (n = 30). Regional homogeneity (ReHo) analysis and functional connectivity analysis were used to identify abnormal brain activity; these abnormalities were compared to tinnitus distress. Results. Relative to healthy controls, tinnitus patients had significant greater ReHo values in several brain regions including the bilateral anterior insula (AI), left inferior frontal gyrus, and right supramarginal gyrus. Furthermore, the left AI showed enhanced functional connectivity with the left middle frontal gyrus (MFG), while the right AI had enhanced functional connectivity with the right MFG; these measures were positively correlated with Tinnitus Handicap Questionnaires (r = 0.459, P = 0.012 and r = 0.479, P = 0.009, resp.). Conclusions. Chronic tinnitus patients showed abnormal intra- and interregional synchronization in several resting-state cerebral networks; these abnormalities were correlated with clinical tinnitus distress. These results suggest that tinnitus distress is exacerbated by attention networks that focus on internally generated phantom sounds. Hindawi Publishing Corporation 2015 2015-02-05 /pmc/articles/PMC4334979/ /pubmed/25734018 http://dx.doi.org/10.1155/2015/475382 Text en Copyright © 2015 Yu-Chen Chen et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Chen, Yu-Chen Zhang, Jian Li, Xiao-Wei Xia, Wenqing Feng, Xu Qian, Cheng Yang, Xiang-Yu Lu, Chun-Qiang Wang, Jian Salvi, Richard Teng, Gao-Jun Altered Intra- and Interregional Synchronization in Resting-State Cerebral Networks Associated with Chronic Tinnitus |
title | Altered Intra- and Interregional Synchronization in Resting-State Cerebral Networks Associated with Chronic Tinnitus |
title_full | Altered Intra- and Interregional Synchronization in Resting-State Cerebral Networks Associated with Chronic Tinnitus |
title_fullStr | Altered Intra- and Interregional Synchronization in Resting-State Cerebral Networks Associated with Chronic Tinnitus |
title_full_unstemmed | Altered Intra- and Interregional Synchronization in Resting-State Cerebral Networks Associated with Chronic Tinnitus |
title_short | Altered Intra- and Interregional Synchronization in Resting-State Cerebral Networks Associated with Chronic Tinnitus |
title_sort | altered intra- and interregional synchronization in resting-state cerebral networks associated with chronic tinnitus |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334979/ https://www.ncbi.nlm.nih.gov/pubmed/25734018 http://dx.doi.org/10.1155/2015/475382 |
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