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Altered Intra- and Interregional Synchronization in Resting-State Cerebral Networks Associated with Chronic Tinnitus

Objective. Subjective tinnitus is hypothesized to arise from aberrant neural activity; however, its neural bases are poorly understood. To identify aberrant neural networks involved in chronic tinnitus, we compared the resting-state functional magnetic resonance imaging (fMRI) patterns of tinnitus p...

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Autores principales: Chen, Yu-Chen, Zhang, Jian, Li, Xiao-Wei, Xia, Wenqing, Feng, Xu, Qian, Cheng, Yang, Xiang-Yu, Lu, Chun-Qiang, Wang, Jian, Salvi, Richard, Teng, Gao-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334979/
https://www.ncbi.nlm.nih.gov/pubmed/25734018
http://dx.doi.org/10.1155/2015/475382
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author Chen, Yu-Chen
Zhang, Jian
Li, Xiao-Wei
Xia, Wenqing
Feng, Xu
Qian, Cheng
Yang, Xiang-Yu
Lu, Chun-Qiang
Wang, Jian
Salvi, Richard
Teng, Gao-Jun
author_facet Chen, Yu-Chen
Zhang, Jian
Li, Xiao-Wei
Xia, Wenqing
Feng, Xu
Qian, Cheng
Yang, Xiang-Yu
Lu, Chun-Qiang
Wang, Jian
Salvi, Richard
Teng, Gao-Jun
author_sort Chen, Yu-Chen
collection PubMed
description Objective. Subjective tinnitus is hypothesized to arise from aberrant neural activity; however, its neural bases are poorly understood. To identify aberrant neural networks involved in chronic tinnitus, we compared the resting-state functional magnetic resonance imaging (fMRI) patterns of tinnitus patients and healthy controls. Materials and Methods. Resting-state fMRI measurements were obtained from a group of chronic tinnitus patients (n = 29) with normal hearing and well-matched healthy controls (n = 30). Regional homogeneity (ReHo) analysis and functional connectivity analysis were used to identify abnormal brain activity; these abnormalities were compared to tinnitus distress. Results. Relative to healthy controls, tinnitus patients had significant greater ReHo values in several brain regions including the bilateral anterior insula (AI), left inferior frontal gyrus, and right supramarginal gyrus. Furthermore, the left AI showed enhanced functional connectivity with the left middle frontal gyrus (MFG), while the right AI had enhanced functional connectivity with the right MFG; these measures were positively correlated with Tinnitus Handicap Questionnaires (r = 0.459, P = 0.012 and r = 0.479, P = 0.009, resp.). Conclusions. Chronic tinnitus patients showed abnormal intra- and interregional synchronization in several resting-state cerebral networks; these abnormalities were correlated with clinical tinnitus distress. These results suggest that tinnitus distress is exacerbated by attention networks that focus on internally generated phantom sounds.
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spelling pubmed-43349792015-03-02 Altered Intra- and Interregional Synchronization in Resting-State Cerebral Networks Associated with Chronic Tinnitus Chen, Yu-Chen Zhang, Jian Li, Xiao-Wei Xia, Wenqing Feng, Xu Qian, Cheng Yang, Xiang-Yu Lu, Chun-Qiang Wang, Jian Salvi, Richard Teng, Gao-Jun Neural Plast Research Article Objective. Subjective tinnitus is hypothesized to arise from aberrant neural activity; however, its neural bases are poorly understood. To identify aberrant neural networks involved in chronic tinnitus, we compared the resting-state functional magnetic resonance imaging (fMRI) patterns of tinnitus patients and healthy controls. Materials and Methods. Resting-state fMRI measurements were obtained from a group of chronic tinnitus patients (n = 29) with normal hearing and well-matched healthy controls (n = 30). Regional homogeneity (ReHo) analysis and functional connectivity analysis were used to identify abnormal brain activity; these abnormalities were compared to tinnitus distress. Results. Relative to healthy controls, tinnitus patients had significant greater ReHo values in several brain regions including the bilateral anterior insula (AI), left inferior frontal gyrus, and right supramarginal gyrus. Furthermore, the left AI showed enhanced functional connectivity with the left middle frontal gyrus (MFG), while the right AI had enhanced functional connectivity with the right MFG; these measures were positively correlated with Tinnitus Handicap Questionnaires (r = 0.459, P = 0.012 and r = 0.479, P = 0.009, resp.). Conclusions. Chronic tinnitus patients showed abnormal intra- and interregional synchronization in several resting-state cerebral networks; these abnormalities were correlated with clinical tinnitus distress. These results suggest that tinnitus distress is exacerbated by attention networks that focus on internally generated phantom sounds. Hindawi Publishing Corporation 2015 2015-02-05 /pmc/articles/PMC4334979/ /pubmed/25734018 http://dx.doi.org/10.1155/2015/475382 Text en Copyright © 2015 Yu-Chen Chen et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Chen, Yu-Chen
Zhang, Jian
Li, Xiao-Wei
Xia, Wenqing
Feng, Xu
Qian, Cheng
Yang, Xiang-Yu
Lu, Chun-Qiang
Wang, Jian
Salvi, Richard
Teng, Gao-Jun
Altered Intra- and Interregional Synchronization in Resting-State Cerebral Networks Associated with Chronic Tinnitus
title Altered Intra- and Interregional Synchronization in Resting-State Cerebral Networks Associated with Chronic Tinnitus
title_full Altered Intra- and Interregional Synchronization in Resting-State Cerebral Networks Associated with Chronic Tinnitus
title_fullStr Altered Intra- and Interregional Synchronization in Resting-State Cerebral Networks Associated with Chronic Tinnitus
title_full_unstemmed Altered Intra- and Interregional Synchronization in Resting-State Cerebral Networks Associated with Chronic Tinnitus
title_short Altered Intra- and Interregional Synchronization in Resting-State Cerebral Networks Associated with Chronic Tinnitus
title_sort altered intra- and interregional synchronization in resting-state cerebral networks associated with chronic tinnitus
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334979/
https://www.ncbi.nlm.nih.gov/pubmed/25734018
http://dx.doi.org/10.1155/2015/475382
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