Interaction between the tRNA-Binding and C-Terminal Domains of Yeast Gcn2 Regulates Kinase Activity In Vivo

The stress-activated protein kinase Gcn2 regulates protein synthesis by phosphorylation of translation initiation factor eIF2α. Gcn2 is activated in amino acid-deprived cells by binding of uncharged tRNA to the regulatory domain related to histidyl-tRNA synthetase, but the molecular mechanism of act...

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Detalles Bibliográficos
Autores principales: Lageix, Sebastien, Zhang, Jinwei, Rothenburg, Stefan, Hinnebusch, Alan G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335047/
https://www.ncbi.nlm.nih.gov/pubmed/25695491
http://dx.doi.org/10.1371/journal.pgen.1004991

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335047/
https://www.ncbi.nlm.nih.gov/pubmed/25695491
http://dx.doi.org/10.1371/journal.pgen.1004991

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