Cargando…

Interaction between the tRNA-Binding and C-Terminal Domains of Yeast Gcn2 Regulates Kinase Activity In Vivo

The stress-activated protein kinase Gcn2 regulates protein synthesis by phosphorylation of translation initiation factor eIF2α. Gcn2 is activated in amino acid-deprived cells by binding of uncharged tRNA to the regulatory domain related to histidyl-tRNA synthetase, but the molecular mechanism of act...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lageix, Sebastien, Zhang, Jinwei, Rothenburg, Stefan, Hinnebusch, Alan G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335047/ https://www.ncbi.nlm.nih.gov/pubmed/25695491 http://dx.doi.org/10.1371/journal.pgen.1004991

Ejemplares similares

Enhanced Interaction between Pseudokinase and Kinase Domains in Gcn2 stimulates eIF2α Phosphorylation in Starved Cells
por: Lageix, Sebastien, et al.
Publicado: (2014)

Differential requirements for P stalk components in activating yeast protein kinase Gcn2 by stalled ribosomes during stress
por: Gupta, Ritu, et al.
Publicado: (2023)

Interplay between GCN2 and GCN4 expression, translation elongation factor 1 mutations and translational fidelity in yeast
por: Magazinnik, Tanya, et al.
Publicado: (2005)

Arabidopsis eIF2α kinase GCN2 is essential for growth in stress conditions and is activated by wounding
por: Lageix, Sébastien, et al.
Publicado: (2008)

An upstream ORF with non-AUG start codon is translated in vivo but dispensable for translational control of GCN4 mRNA
por: Zhang, Fan, et al.
Publicado: (2011)

GCN sensitive protein translation in yeast
por: Barr, William A., et al.
Publicado: (2020)

C-terminal domain of archaeal O-phosphoseryl-tRNA kinase displays large-scale motion to bind the 7-bp D-stem of archaeal tRNA(Sec)
por: Sherrer, R. Lynn, et al.
Publicado: (2011)

A Plant Virus Movement Protein Regulates the Gcn2p Kinase in Budding Yeast
por: Aparicio, Frederic, et al.
Publicado: (2011)

Accumulation of a Threonine Biosynthetic Intermediate Attenuates General Amino Acid Control by Accelerating Degradation of Gcn4 via Pho85 and Cdk8
por: Rawal, Yashpal, et al.
Publicado: (2014)

Double-stranded RNA-activated protein kinase PKR of fishes and amphibians: Varying the number of double-stranded RNA binding domains and lineage-specific duplications
por: Rothenburg, Stefan, et al.
Publicado: (2008)

Antagonistic Gcn5-Hda1 interactions revealed by mutations to the Anaphase Promoting Complex in yeast
por: Islam, Azharul, et al.
Publicado: (2011)

ZBP1 subcellular localization and association with stress granules is controlled by its Z-DNA binding domains
por: Deigendesch, Nikolaus, et al.
Publicado: (2006)

Recognition of a structural domain (RWDBD) in Gcn1 proteins that interacts with the RWD domain containing proteins
por: Rakesh, Ramachandran, et al.
Publicado: (2017)

Conserved residues in yeast initiator tRNA calibrate initiation accuracy by regulating preinitiation complex stability at the start codon
por: Dong, Jinsheng, et al.
Publicado: (2014)

A network of eIF2β interactions with eIF1 and Met-tRNA(i) promotes accurate start codon selection by the translation preinitiation complex
por: Thakur, Anil, et al.
Publicado: (2019)

Multiomics of GCN4-Dependent Replicative Lifespan Extension Models Reveals Gcn4 as a Regulator of Protein Turnover in Yeast
por: Mariner, Blaise L., et al.
Publicado: (2023)

Gcn4 impacts metabolic fluxes to promote yeast chronological lifespan
por: Gulias, Juan Facundo, et al.
Publicado: (2023)

Structure–function analysis of the kinase-CPD domain of yeast tRNA ligase (Trl1) and requirements for complementation of tRNA splicing by a plant Trl1 homolog
por: Wang, Li Kai, et al.
Publicado: (2006)

The C-terminal domain of yeast PCNA is required for physical and functional interactions with Cdc9 DNA ligase
por: Vijayakumar, Sangeetha, et al.
Publicado: (2007)

YeastBook: An Encyclopedia of the Reference Eukaryotic Cell
por: Hinnebusch, Alan G., et al.
Publicado: (2011)

Protein kinase GCN2 mediates responses to glyphosate in Arabidopsis
por: Faus, Isabel, et al.
Publicado: (2015)

Yeast eIF2A has a minimal role in translation initiation and uORF-mediated translational control in vivo
por: Gaikwad, Swati, et al.
Publicado: (2023)

Genome-wide cooperation by HAT Gcn5, remodeler SWI/SNF, and chaperone Ydj1 in promoter nucleosome eviction and transcriptional activation
por: Qiu, Hongfang, et al.
Publicado: (2016)

The Gcn2 Regulator Yih1 Interacts with the Cyclin Dependent Kinase Cdc28 and Promotes Cell Cycle Progression through G2/M in Budding Yeast
por: Silva, Richard C., et al.
Publicado: (2015)

Mediator subunit Med15 dictates the conserved “fuzzy” binding mechanism of yeast transcription activators Gal4 and Gcn4
por: Tuttle, Lisa M., et al.
Publicado: (2021)

Coexistence of bacterial leucyl-tRNA synthetases with archaeal tRNA binding domains that distinguish tRNA(Leu) in the archaeal mode
por: Fang, Zhi-Peng, et al.
Publicado: (2014)

Tripartite suppression of fission yeast TORC1 signaling by the GATOR1-Sea3 complex, the TSC complex, and Gcn2 kinase
por: Fukuda, Tomoyuki, et al.
Publicado: (2021)

The molecular aetiology of tRNA synthetase depletion: induction of a GCN4 amino acid starvation response despite homeostatic maintenance of charged tRNA levels
por: McFarland, Matthew R, et al.
Publicado: (2020)

The methyltransferase TrmA facilitates tRNA folding through interaction with its RNA-binding domain
por: Keffer-Wilkes, Laura Carole, et al.
Publicado: (2020)

Cytosolic and mitochondrial tRNA synthetase inhibitors increase lifespan in a GCN4/atf-4-dependent manner
por: Robbins, Christine E., et al.
Publicado: (2022)

Analysing GCN4 translational control in yeast by stochastic chemical kinetics modelling and simulation
por: You, Tao, et al.
Publicado: (2011)

The Gcn4 transcription factor reduces protein synthesis capacity and extends yeast lifespan
por: Mittal, Nitish, et al.
Publicado: (2017)

Arabidopsis GCN2 kinase contributes to ABA homeostasis and stomatal immunity
por: Liu, Xiaoyu, et al.
Publicado: (2019)

PPA-GCN: A Efficient GCN Framework for Prokaryotic Pathways Assignment
por: Lu, Yuntao, et al.
Publicado: (2022)

Yeast arginine methyltransferase Hmt1p regulates transcription elongation and termination by methylating Npl3p
por: Wong, Chi-Ming, et al.
Publicado: (2010)

The phenotypic expression of mitochondrial tRNA-mutations can be modulated by either mitochondrial leucyl-tRNA synthetase or the C-terminal domain thereof
por: Giordano, Carla, et al.
Publicado: (2015)

The Leucine Zipper Domains of the Transcription Factors GCN4 and c-Jun Have Ribonuclease Activity
por: Nikolaev, Yaroslav, et al.
Publicado: (2010)

Interaction of the p53 DNA-Binding Domain with Its N-Terminal Extension Modulates the Stability of the p53 Tetramer
por: Natan, Eviatar, et al.
Publicado: (2011)

Chromatin binding of Gcn5 in Drosophila is largely mediated by CP190
por: Ali, Tamer, et al.
Publicado: (2017)

The p53 tetramer shows an induced-fit interaction of the C-terminal domain with the DNA-binding domain
por: D'Abramo, M, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_iha1505n0nnia8c7bgfvpu7gic