Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of Nebulized Sodium Nitrite (AIR001) Following Repeat-Dose Inhalation in Healthy Subjects

INTRODUCTION: The efficacy of nebulized sodium nitrite (AIR001) has been demonstrated in animal models of pulmonary arterial hypertension (PAH), but it was not known if inhaled nitrite would be well tolerated in human subjects at exposure levels associated with efficacy in these models. METHODS: Inh...

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Detalles Bibliográficos
Autores principales: Rix, Peter J., Vick, Andrew, Attkins, Neil J., Barker, Geoffrey E., Bott, Adrian W., Alcorn, Harry, Gladwin, Mark T., Shiva, Sruti, Bradley, Stephen, Hussaini, Azra, Hoye, William L., Parsley, Ed L., Masamune, Hiroko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2014
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335132/
https://www.ncbi.nlm.nih.gov/pubmed/25421879
http://dx.doi.org/10.1007/s40262-014-0201-y

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