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(99m)Tc-Phytate Lymphoscintigraphy for Detection of Sentinel Node: Preliminary Results of the First Year's Clinical Experience in Isfahan, Iran

Sentinel lymph node is the first regional lymph node that drains the lymph from the primary tumor. It is potentially the first node to receive the seeding of lymph-borne metastatic cells. This study aimed to discuss lymphoscintigraphy procedural guidelines for detection of sentinel node using (99m)T...

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Autores principales: Moslehi, Masoud, Shanei, Ahmad, Hakimian, Seyyed Mohammad Reza, Mahmoudi, Golshan, Baradaran-Ghahfarokhi, Milad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335147/
https://www.ncbi.nlm.nih.gov/pubmed/25709943
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author Moslehi, Masoud
Shanei, Ahmad
Hakimian, Seyyed Mohammad Reza
Mahmoudi, Golshan
Baradaran-Ghahfarokhi, Milad
author_facet Moslehi, Masoud
Shanei, Ahmad
Hakimian, Seyyed Mohammad Reza
Mahmoudi, Golshan
Baradaran-Ghahfarokhi, Milad
author_sort Moslehi, Masoud
collection PubMed
description Sentinel lymph node is the first regional lymph node that drains the lymph from the primary tumor. It is potentially the first node to receive the seeding of lymph-borne metastatic cells. This study aimed to discuss lymphoscintigraphy procedural guidelines for detection of sentinel node using (99m)Tc-Phytate in Isfahan, Iran. Moreover, the preliminary results of the first year's clinical experience of lymphoscintigraphy in Isfahan, Iran are also presented. A total of 36 consecutive sentinel node procedures were performed following our protocol in March 2013 to March 2014. For all 36 patients, after intradermal injection of 0.5–1 mCi of (99m)Tc-Phytate, 5, 30 and 120 min with hands up lymphoscintigraphy was performed. All procedures were performed in a 1-day setting with (99m)Tc-Phytate injection in intradermal volume of about 0.1 cc. At 5, 30 and 120 min after injection, anterior and lateral images (4 min), were acquired using gamma-camera (energy 140 keV, window 15–20% and LEHR collimator). For all patients, at least one axillary sentinel lymph node was detected. For three patients, 2 SNs were seen. The images 5 min after injection showed at least one axillary sentinel node in 18 of 36 patients. However for the remaining patients, more delayed images (after 30 and 120 min) were needed. Although, no changes were seen in 120 min images compared to 30 min images. Considering the used protocol, from the evaluated data it can be concluded that lymphoscintigraphy after 30 min periareolar injection of about 0.5–1 mCi (99m)Tc-Phytate in an intradermal volume of about 0.1 cc yields an axillary sentinel node in all the patients. Imaging 120 min after injection is of no additional value and can be omitted.
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spelling pubmed-43351472015-02-23 (99m)Tc-Phytate Lymphoscintigraphy for Detection of Sentinel Node: Preliminary Results of the First Year's Clinical Experience in Isfahan, Iran Moslehi, Masoud Shanei, Ahmad Hakimian, Seyyed Mohammad Reza Mahmoudi, Golshan Baradaran-Ghahfarokhi, Milad J Med Signals Sens Short Communication Sentinel lymph node is the first regional lymph node that drains the lymph from the primary tumor. It is potentially the first node to receive the seeding of lymph-borne metastatic cells. This study aimed to discuss lymphoscintigraphy procedural guidelines for detection of sentinel node using (99m)Tc-Phytate in Isfahan, Iran. Moreover, the preliminary results of the first year's clinical experience of lymphoscintigraphy in Isfahan, Iran are also presented. A total of 36 consecutive sentinel node procedures were performed following our protocol in March 2013 to March 2014. For all 36 patients, after intradermal injection of 0.5–1 mCi of (99m)Tc-Phytate, 5, 30 and 120 min with hands up lymphoscintigraphy was performed. All procedures were performed in a 1-day setting with (99m)Tc-Phytate injection in intradermal volume of about 0.1 cc. At 5, 30 and 120 min after injection, anterior and lateral images (4 min), were acquired using gamma-camera (energy 140 keV, window 15–20% and LEHR collimator). For all patients, at least one axillary sentinel lymph node was detected. For three patients, 2 SNs were seen. The images 5 min after injection showed at least one axillary sentinel node in 18 of 36 patients. However for the remaining patients, more delayed images (after 30 and 120 min) were needed. Although, no changes were seen in 120 min images compared to 30 min images. Considering the used protocol, from the evaluated data it can be concluded that lymphoscintigraphy after 30 min periareolar injection of about 0.5–1 mCi (99m)Tc-Phytate in an intradermal volume of about 0.1 cc yields an axillary sentinel node in all the patients. Imaging 120 min after injection is of no additional value and can be omitted. Medknow Publications & Media Pvt Ltd 2015 /pmc/articles/PMC4335147/ /pubmed/25709943 Text en Copyright: © Journal of Medical Signals and Sensors http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Moslehi, Masoud
Shanei, Ahmad
Hakimian, Seyyed Mohammad Reza
Mahmoudi, Golshan
Baradaran-Ghahfarokhi, Milad
(99m)Tc-Phytate Lymphoscintigraphy for Detection of Sentinel Node: Preliminary Results of the First Year's Clinical Experience in Isfahan, Iran
title (99m)Tc-Phytate Lymphoscintigraphy for Detection of Sentinel Node: Preliminary Results of the First Year's Clinical Experience in Isfahan, Iran
title_full (99m)Tc-Phytate Lymphoscintigraphy for Detection of Sentinel Node: Preliminary Results of the First Year's Clinical Experience in Isfahan, Iran
title_fullStr (99m)Tc-Phytate Lymphoscintigraphy for Detection of Sentinel Node: Preliminary Results of the First Year's Clinical Experience in Isfahan, Iran
title_full_unstemmed (99m)Tc-Phytate Lymphoscintigraphy for Detection of Sentinel Node: Preliminary Results of the First Year's Clinical Experience in Isfahan, Iran
title_short (99m)Tc-Phytate Lymphoscintigraphy for Detection of Sentinel Node: Preliminary Results of the First Year's Clinical Experience in Isfahan, Iran
title_sort (99m)tc-phytate lymphoscintigraphy for detection of sentinel node: preliminary results of the first year's clinical experience in isfahan, iran
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335147/
https://www.ncbi.nlm.nih.gov/pubmed/25709943
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