Partially Redundant Enhancers Cooperatively Maintain Mammalian Pomc Expression Above a Critical Functional Threshold

Cell-specific expression of many genes is conveyed by multiple enhancers, with each individual enhancer controlling a particular expression domain. In contrast, multiple enhancers drive similar expression patterns of some genes involved in embryonic development, suggesting regulatory redundancy. Wor...

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Detalles Bibliográficos
Autores principales: Lam, Daniel D., de Souza, Flavio S. J., Nasif, Sofia, Yamashita, Miho, López-Leal, Rodrigo, Otero-Corchon, Veronica, Meece, Kana, Sampath, Harini, Mercer, Aaron J., Wardlaw, Sharon L., Rubinstein, Marcelo, Low, Malcolm J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335486/
https://www.ncbi.nlm.nih.gov/pubmed/25671638
http://dx.doi.org/10.1371/journal.pgen.1004935

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