Diverse Heterologous Primary Infections Radically Alter Immunodominance Hierarchies and Clinical Outcomes Following H7N9 Influenza Challenge in Mice

The recent emergence of a novel H7N9 influenza A virus (IAV) causing severe human infections in China raises concerns about a possible pandemic. The lack of pre-existing neutralizing antibodies in the broader population highlights the potential protective role of IAV-specific CD8+ cytotoxic T lympho...

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Detalles Bibliográficos
Autores principales: Duan, Susu, Meliopoulos, Victoria A., McClaren, Jennifer L., Guo, Xi-Zhi J., Sanders, Catherine J., Smallwood, Heather S., Webby, Richard J., Schultz-Cherry, Stacey L., Doherty, Peter C., Thomas, Paul G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335497/
https://www.ncbi.nlm.nih.gov/pubmed/25668410
http://dx.doi.org/10.1371/journal.ppat.1004642

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