The three-body problem of therapy with induced pluripotent stem cells

Regenerative medicine has a three-body problem: alignment of the dynamics of the genome, stem cell and patient. Focusing on the rare inherited fragile skin disorder epidermolysis bullosa, three recent innovative studies have used induced pluripotent stem cells and gene correction, revertant mosaicis...

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Detalles Bibliográficos
Autores principales: Tolar, Jakub, McGrath, John A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Highlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335559/
https://www.ncbi.nlm.nih.gov/pubmed/25705260
http://dx.doi.org/10.1186/s13073-015-0141-7
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author Tolar, Jakub
McGrath, John A
author_facet Tolar, Jakub
McGrath, John A
author_sort Tolar, Jakub
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description Regenerative medicine has a three-body problem: alignment of the dynamics of the genome, stem cell and patient. Focusing on the rare inherited fragile skin disorder epidermolysis bullosa, three recent innovative studies have used induced pluripotent stem cells and gene correction, revertant mosaicism or genome editing to advance the prospects of better cell-based therapeutics to restore skin structure and function for epidermolysis bullosa and potentially other inherited diseases.
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spelling pubmed-43355592015-02-21 The three-body problem of therapy with induced pluripotent stem cells Tolar, Jakub McGrath, John A Genome Med Research Highlight Regenerative medicine has a three-body problem: alignment of the dynamics of the genome, stem cell and patient. Focusing on the rare inherited fragile skin disorder epidermolysis bullosa, three recent innovative studies have used induced pluripotent stem cells and gene correction, revertant mosaicism or genome editing to advance the prospects of better cell-based therapeutics to restore skin structure and function for epidermolysis bullosa and potentially other inherited diseases. BioMed Central 2015-02-20 /pmc/articles/PMC4335559/ /pubmed/25705260 http://dx.doi.org/10.1186/s13073-015-0141-7 Text en © Tolar and McGrath; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Highlight
Tolar, Jakub
McGrath, John A
The three-body problem of therapy with induced pluripotent stem cells
title The three-body problem of therapy with induced pluripotent stem cells
title_full The three-body problem of therapy with induced pluripotent stem cells
title_fullStr The three-body problem of therapy with induced pluripotent stem cells
title_full_unstemmed The three-body problem of therapy with induced pluripotent stem cells
title_short The three-body problem of therapy with induced pluripotent stem cells
title_sort three-body problem of therapy with induced pluripotent stem cells
topic Research Highlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335559/
https://www.ncbi.nlm.nih.gov/pubmed/25705260
http://dx.doi.org/10.1186/s13073-015-0141-7
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