Molecular screening for Epstein Barr virus (EBV) among Sudanese patients with nasopharyngeal carcinoma (NPC)

OBJECTIVE: The aim of this study was to screen for the presence of Epstein Barr Virus (EBV) among Sudanese patients with Nasopharyngeal Carcinoma (NPC). METHODS: In this study, 150 tissue samples that were previously diagnosed as having NPC were screened for the presence of EBV using Polymerase Chai...

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Autores principales: Ahmed, Hussain Gadelkarim, Suliman, Rania Saad Abdul Gader, El Aziz, Mohammed Siddig Abd, Alshammari, Fawaz D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335634/
https://www.ncbi.nlm.nih.gov/pubmed/25705250
http://dx.doi.org/10.1186/s13027-015-0002-4
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author Ahmed, Hussain Gadelkarim
Suliman, Rania Saad Abdul Gader
El Aziz, Mohammed Siddig Abd
Alshammari, Fawaz D
author_facet Ahmed, Hussain Gadelkarim
Suliman, Rania Saad Abdul Gader
El Aziz, Mohammed Siddig Abd
Alshammari, Fawaz D
author_sort Ahmed, Hussain Gadelkarim
collection PubMed
description OBJECTIVE: The aim of this study was to screen for the presence of Epstein Barr Virus (EBV) among Sudanese patients with Nasopharyngeal Carcinoma (NPC). METHODS: In this study, 150 tissue samples that were previously diagnosed as having NPC were screened for the presence of EBV using Polymerase Chain Reaction (PCR). PCR was performed to amplify two viral genes; EBV nuclear antigen-4 (EBNA-4) and latent membrane protein-1 (LMP1). RESULTS: EBV genes were detected in 92/150 (61.3%) tissue samples. Of the 92 infected samples, 58/92 (63%) were found among males and 34/92 (37%) were among females. CONCLUSION: EBV is prevalent in the Sudan and responsible of the vast majority of cases of NPC.
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spelling pubmed-43356342015-02-21 Molecular screening for Epstein Barr virus (EBV) among Sudanese patients with nasopharyngeal carcinoma (NPC) Ahmed, Hussain Gadelkarim Suliman, Rania Saad Abdul Gader El Aziz, Mohammed Siddig Abd Alshammari, Fawaz D Infect Agent Cancer Research Article OBJECTIVE: The aim of this study was to screen for the presence of Epstein Barr Virus (EBV) among Sudanese patients with Nasopharyngeal Carcinoma (NPC). METHODS: In this study, 150 tissue samples that were previously diagnosed as having NPC were screened for the presence of EBV using Polymerase Chain Reaction (PCR). PCR was performed to amplify two viral genes; EBV nuclear antigen-4 (EBNA-4) and latent membrane protein-1 (LMP1). RESULTS: EBV genes were detected in 92/150 (61.3%) tissue samples. Of the 92 infected samples, 58/92 (63%) were found among males and 34/92 (37%) were among females. CONCLUSION: EBV is prevalent in the Sudan and responsible of the vast majority of cases of NPC. BioMed Central 2015-02-17 /pmc/articles/PMC4335634/ /pubmed/25705250 http://dx.doi.org/10.1186/s13027-015-0002-4 Text en © Ahmed et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Ahmed, Hussain Gadelkarim
Suliman, Rania Saad Abdul Gader
El Aziz, Mohammed Siddig Abd
Alshammari, Fawaz D
Molecular screening for Epstein Barr virus (EBV) among Sudanese patients with nasopharyngeal carcinoma (NPC)
title Molecular screening for Epstein Barr virus (EBV) among Sudanese patients with nasopharyngeal carcinoma (NPC)
title_full Molecular screening for Epstein Barr virus (EBV) among Sudanese patients with nasopharyngeal carcinoma (NPC)
title_fullStr Molecular screening for Epstein Barr virus (EBV) among Sudanese patients with nasopharyngeal carcinoma (NPC)
title_full_unstemmed Molecular screening for Epstein Barr virus (EBV) among Sudanese patients with nasopharyngeal carcinoma (NPC)
title_short Molecular screening for Epstein Barr virus (EBV) among Sudanese patients with nasopharyngeal carcinoma (NPC)
title_sort molecular screening for epstein barr virus (ebv) among sudanese patients with nasopharyngeal carcinoma (npc)
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335634/
https://www.ncbi.nlm.nih.gov/pubmed/25705250
http://dx.doi.org/10.1186/s13027-015-0002-4
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