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Efficiency of hydrogen peroxide in improving disinfection of ICU rooms
INTRODUCTION: The primary objective of this study was to determine the efficiency of hydrogen peroxide (H(2)O(2)) techniques in disinfection of ICU rooms contaminated with multidrug-resistant organisms (MDRO) after patient discharge. Secondary objectives included comparison of the efficiency of a va...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335785/ https://www.ncbi.nlm.nih.gov/pubmed/25641219 http://dx.doi.org/10.1186/s13054-015-0752-9 |
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author | Blazejewski, Caroline Wallet, Frédéric Rouzé, Anahita Le Guern, Rémi Ponthieux, Sylvie Salleron, Julia Nseir, Saad |
author_facet | Blazejewski, Caroline Wallet, Frédéric Rouzé, Anahita Le Guern, Rémi Ponthieux, Sylvie Salleron, Julia Nseir, Saad |
author_sort | Blazejewski, Caroline |
collection | PubMed |
description | INTRODUCTION: The primary objective of this study was to determine the efficiency of hydrogen peroxide (H(2)O(2)) techniques in disinfection of ICU rooms contaminated with multidrug-resistant organisms (MDRO) after patient discharge. Secondary objectives included comparison of the efficiency of a vaporizator (HPV, Bioquell®) and an aerosolizer using H(2)O(2), and peracetic acid (aHPP, Anios®) in MDRO environmental disinfection, and assessment of toxicity of these techniques. METHODS: This prospective cross-over study was conducted in five medical and surgical ICUs located in one University hospital, during a 12-week period. Routine terminal cleaning was followed by H(2)O(2) disinfection. A total of 24 environmental bacteriological samplings were collected per room, from eight frequently touched surfaces, at three time-points: after patient discharge (T0), after terminal cleaning (T1) and after H(2)O(2) disinfection (T2). RESULTS: In total 182 rooms were studied, including 89 (49%) disinfected with aHPP and 93 (51%) with HPV. At T0, 15/182 (8%) rooms were contaminated with at least 1 MDRO (extended spectrum β–lactamase-producing Gram-negative bacilli 50%, imipenem resistant Acinetobacter baumannii 29%, methicillin-resistant Staphylococcus aureus 17%, and Pseudomonas aeruginosa resistant to ceftazidime or imipenem 4%). Routine terminal cleaning reduced environmental bacterial load (P <0.001) without efficiency on MDRO (15/182 (8%) rooms at T0 versus 11/182 (6%) at T1; P = 0.371). H(2)O(2) technologies were efficient for environmental MDRO decontamination (6% of rooms contaminated with MDRO at T1 versus 0.5% at T2, P = 0.004). Patient characteristics were similar in aHPP and HPV groups. No significant difference was found between aHPP and HPV regarding the rate of rooms contaminated with MDRO at T2 (P = 0.313). 42% of room occupants were MDRO carriers. The highest rate of rooms contaminated with MDRO was found in rooms where patients stayed for a longer period of time, and where a patient with MDRO was hospitalized. The residual concentration of H(2)O(2) appears to be higher using aHPP, compared with HPV. CONCLUSIONS: H(2)O(2) treatment is efficient in reducing MDRO contaminated rooms in the ICU. No significant difference was found between aHPP and HPV regarding their disinfection efficiency. |
format | Online Article Text |
id | pubmed-4335785 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-43357852015-02-21 Efficiency of hydrogen peroxide in improving disinfection of ICU rooms Blazejewski, Caroline Wallet, Frédéric Rouzé, Anahita Le Guern, Rémi Ponthieux, Sylvie Salleron, Julia Nseir, Saad Crit Care Research INTRODUCTION: The primary objective of this study was to determine the efficiency of hydrogen peroxide (H(2)O(2)) techniques in disinfection of ICU rooms contaminated with multidrug-resistant organisms (MDRO) after patient discharge. Secondary objectives included comparison of the efficiency of a vaporizator (HPV, Bioquell®) and an aerosolizer using H(2)O(2), and peracetic acid (aHPP, Anios®) in MDRO environmental disinfection, and assessment of toxicity of these techniques. METHODS: This prospective cross-over study was conducted in five medical and surgical ICUs located in one University hospital, during a 12-week period. Routine terminal cleaning was followed by H(2)O(2) disinfection. A total of 24 environmental bacteriological samplings were collected per room, from eight frequently touched surfaces, at three time-points: after patient discharge (T0), after terminal cleaning (T1) and after H(2)O(2) disinfection (T2). RESULTS: In total 182 rooms were studied, including 89 (49%) disinfected with aHPP and 93 (51%) with HPV. At T0, 15/182 (8%) rooms were contaminated with at least 1 MDRO (extended spectrum β–lactamase-producing Gram-negative bacilli 50%, imipenem resistant Acinetobacter baumannii 29%, methicillin-resistant Staphylococcus aureus 17%, and Pseudomonas aeruginosa resistant to ceftazidime or imipenem 4%). Routine terminal cleaning reduced environmental bacterial load (P <0.001) without efficiency on MDRO (15/182 (8%) rooms at T0 versus 11/182 (6%) at T1; P = 0.371). H(2)O(2) technologies were efficient for environmental MDRO decontamination (6% of rooms contaminated with MDRO at T1 versus 0.5% at T2, P = 0.004). Patient characteristics were similar in aHPP and HPV groups. No significant difference was found between aHPP and HPV regarding the rate of rooms contaminated with MDRO at T2 (P = 0.313). 42% of room occupants were MDRO carriers. The highest rate of rooms contaminated with MDRO was found in rooms where patients stayed for a longer period of time, and where a patient with MDRO was hospitalized. The residual concentration of H(2)O(2) appears to be higher using aHPP, compared with HPV. CONCLUSIONS: H(2)O(2) treatment is efficient in reducing MDRO contaminated rooms in the ICU. No significant difference was found between aHPP and HPV regarding their disinfection efficiency. BioMed Central 2015-02-02 2015 /pmc/articles/PMC4335785/ /pubmed/25641219 http://dx.doi.org/10.1186/s13054-015-0752-9 Text en © Blazejewski et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Blazejewski, Caroline Wallet, Frédéric Rouzé, Anahita Le Guern, Rémi Ponthieux, Sylvie Salleron, Julia Nseir, Saad Efficiency of hydrogen peroxide in improving disinfection of ICU rooms |
title | Efficiency of hydrogen peroxide in improving disinfection of ICU rooms |
title_full | Efficiency of hydrogen peroxide in improving disinfection of ICU rooms |
title_fullStr | Efficiency of hydrogen peroxide in improving disinfection of ICU rooms |
title_full_unstemmed | Efficiency of hydrogen peroxide in improving disinfection of ICU rooms |
title_short | Efficiency of hydrogen peroxide in improving disinfection of ICU rooms |
title_sort | efficiency of hydrogen peroxide in improving disinfection of icu rooms |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335785/ https://www.ncbi.nlm.nih.gov/pubmed/25641219 http://dx.doi.org/10.1186/s13054-015-0752-9 |
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