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Efficiency of hydrogen peroxide in improving disinfection of ICU rooms

INTRODUCTION: The primary objective of this study was to determine the efficiency of hydrogen peroxide (H(2)O(2)) techniques in disinfection of ICU rooms contaminated with multidrug-resistant organisms (MDRO) after patient discharge. Secondary objectives included comparison of the efficiency of a va...

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Autores principales: Blazejewski, Caroline, Wallet, Frédéric, Rouzé, Anahita, Le Guern, Rémi, Ponthieux, Sylvie, Salleron, Julia, Nseir, Saad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335785/
https://www.ncbi.nlm.nih.gov/pubmed/25641219
http://dx.doi.org/10.1186/s13054-015-0752-9
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author Blazejewski, Caroline
Wallet, Frédéric
Rouzé, Anahita
Le Guern, Rémi
Ponthieux, Sylvie
Salleron, Julia
Nseir, Saad
author_facet Blazejewski, Caroline
Wallet, Frédéric
Rouzé, Anahita
Le Guern, Rémi
Ponthieux, Sylvie
Salleron, Julia
Nseir, Saad
author_sort Blazejewski, Caroline
collection PubMed
description INTRODUCTION: The primary objective of this study was to determine the efficiency of hydrogen peroxide (H(2)O(2)) techniques in disinfection of ICU rooms contaminated with multidrug-resistant organisms (MDRO) after patient discharge. Secondary objectives included comparison of the efficiency of a vaporizator (HPV, Bioquell®) and an aerosolizer using H(2)O(2), and peracetic acid (aHPP, Anios®) in MDRO environmental disinfection, and assessment of toxicity of these techniques. METHODS: This prospective cross-over study was conducted in five medical and surgical ICUs located in one University hospital, during a 12-week period. Routine terminal cleaning was followed by H(2)O(2) disinfection. A total of 24 environmental bacteriological samplings were collected per room, from eight frequently touched surfaces, at three time-points: after patient discharge (T0), after terminal cleaning (T1) and after H(2)O(2) disinfection (T2). RESULTS: In total 182 rooms were studied, including 89 (49%) disinfected with aHPP and 93 (51%) with HPV. At T0, 15/182 (8%) rooms were contaminated with at least 1 MDRO (extended spectrum β–lactamase-producing Gram-negative bacilli 50%, imipenem resistant Acinetobacter baumannii 29%, methicillin-resistant Staphylococcus aureus 17%, and Pseudomonas aeruginosa resistant to ceftazidime or imipenem 4%). Routine terminal cleaning reduced environmental bacterial load (P <0.001) without efficiency on MDRO (15/182 (8%) rooms at T0 versus 11/182 (6%) at T1; P = 0.371). H(2)O(2) technologies were efficient for environmental MDRO decontamination (6% of rooms contaminated with MDRO at T1 versus 0.5% at T2, P = 0.004). Patient characteristics were similar in aHPP and HPV groups. No significant difference was found between aHPP and HPV regarding the rate of rooms contaminated with MDRO at T2 (P = 0.313). 42% of room occupants were MDRO carriers. The highest rate of rooms contaminated with MDRO was found in rooms where patients stayed for a longer period of time, and where a patient with MDRO was hospitalized. The residual concentration of H(2)O(2) appears to be higher using aHPP, compared with HPV. CONCLUSIONS: H(2)O(2) treatment is efficient in reducing MDRO contaminated rooms in the ICU. No significant difference was found between aHPP and HPV regarding their disinfection efficiency.
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spelling pubmed-43357852015-02-21 Efficiency of hydrogen peroxide in improving disinfection of ICU rooms Blazejewski, Caroline Wallet, Frédéric Rouzé, Anahita Le Guern, Rémi Ponthieux, Sylvie Salleron, Julia Nseir, Saad Crit Care Research INTRODUCTION: The primary objective of this study was to determine the efficiency of hydrogen peroxide (H(2)O(2)) techniques in disinfection of ICU rooms contaminated with multidrug-resistant organisms (MDRO) after patient discharge. Secondary objectives included comparison of the efficiency of a vaporizator (HPV, Bioquell®) and an aerosolizer using H(2)O(2), and peracetic acid (aHPP, Anios®) in MDRO environmental disinfection, and assessment of toxicity of these techniques. METHODS: This prospective cross-over study was conducted in five medical and surgical ICUs located in one University hospital, during a 12-week period. Routine terminal cleaning was followed by H(2)O(2) disinfection. A total of 24 environmental bacteriological samplings were collected per room, from eight frequently touched surfaces, at three time-points: after patient discharge (T0), after terminal cleaning (T1) and after H(2)O(2) disinfection (T2). RESULTS: In total 182 rooms were studied, including 89 (49%) disinfected with aHPP and 93 (51%) with HPV. At T0, 15/182 (8%) rooms were contaminated with at least 1 MDRO (extended spectrum β–lactamase-producing Gram-negative bacilli 50%, imipenem resistant Acinetobacter baumannii 29%, methicillin-resistant Staphylococcus aureus 17%, and Pseudomonas aeruginosa resistant to ceftazidime or imipenem 4%). Routine terminal cleaning reduced environmental bacterial load (P <0.001) without efficiency on MDRO (15/182 (8%) rooms at T0 versus 11/182 (6%) at T1; P = 0.371). H(2)O(2) technologies were efficient for environmental MDRO decontamination (6% of rooms contaminated with MDRO at T1 versus 0.5% at T2, P = 0.004). Patient characteristics were similar in aHPP and HPV groups. No significant difference was found between aHPP and HPV regarding the rate of rooms contaminated with MDRO at T2 (P = 0.313). 42% of room occupants were MDRO carriers. The highest rate of rooms contaminated with MDRO was found in rooms where patients stayed for a longer period of time, and where a patient with MDRO was hospitalized. The residual concentration of H(2)O(2) appears to be higher using aHPP, compared with HPV. CONCLUSIONS: H(2)O(2) treatment is efficient in reducing MDRO contaminated rooms in the ICU. No significant difference was found between aHPP and HPV regarding their disinfection efficiency. BioMed Central 2015-02-02 2015 /pmc/articles/PMC4335785/ /pubmed/25641219 http://dx.doi.org/10.1186/s13054-015-0752-9 Text en © Blazejewski et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Blazejewski, Caroline
Wallet, Frédéric
Rouzé, Anahita
Le Guern, Rémi
Ponthieux, Sylvie
Salleron, Julia
Nseir, Saad
Efficiency of hydrogen peroxide in improving disinfection of ICU rooms
title Efficiency of hydrogen peroxide in improving disinfection of ICU rooms
title_full Efficiency of hydrogen peroxide in improving disinfection of ICU rooms
title_fullStr Efficiency of hydrogen peroxide in improving disinfection of ICU rooms
title_full_unstemmed Efficiency of hydrogen peroxide in improving disinfection of ICU rooms
title_short Efficiency of hydrogen peroxide in improving disinfection of ICU rooms
title_sort efficiency of hydrogen peroxide in improving disinfection of icu rooms
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335785/
https://www.ncbi.nlm.nih.gov/pubmed/25641219
http://dx.doi.org/10.1186/s13054-015-0752-9
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