The phosphoinositide 3-kinase pathway and therapy resistance in cancer

The phosphoinositide 3-kinase (PI3K)/Akt/mechanistic target of rapamycin (mTOR) signaling network is a master regulator of processes that contribute to tumorigenesis and tumor maintenance. The PI3K pathway also plays a critical role in driving resistance to diverse anti-cancer therapies. This review...

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Detalles Bibliográficos
Autores principales: Brown, Kristin K., Toker, Alex
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Faculty of 1000 Ltd 2015
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335789/
https://www.ncbi.nlm.nih.gov/pubmed/25750731
http://dx.doi.org/10.12703/P7-13
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author Brown, Kristin K.
Toker, Alex
author_facet Brown, Kristin K.
Toker, Alex
author_sort Brown, Kristin K.
collection PubMed
description The phosphoinositide 3-kinase (PI3K)/Akt/mechanistic target of rapamycin (mTOR) signaling network is a master regulator of processes that contribute to tumorigenesis and tumor maintenance. The PI3K pathway also plays a critical role in driving resistance to diverse anti-cancer therapies. This review article focuses on mechanisms by which the PI3K pathway contributes to therapy resistance in cancer, and highlights potential combination therapy strategies to circumvent resistance driven by PI3K signaling. In addition, resistance mechanisms that limit the clinical efficacy of small molecule inhibitors of the PI3K pathway are discussed.
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spelling pubmed-43357892015-03-06 The phosphoinositide 3-kinase pathway and therapy resistance in cancer Brown, Kristin K. Toker, Alex F1000Prime Rep Review Article The phosphoinositide 3-kinase (PI3K)/Akt/mechanistic target of rapamycin (mTOR) signaling network is a master regulator of processes that contribute to tumorigenesis and tumor maintenance. The PI3K pathway also plays a critical role in driving resistance to diverse anti-cancer therapies. This review article focuses on mechanisms by which the PI3K pathway contributes to therapy resistance in cancer, and highlights potential combination therapy strategies to circumvent resistance driven by PI3K signaling. In addition, resistance mechanisms that limit the clinical efficacy of small molecule inhibitors of the PI3K pathway are discussed. Faculty of 1000 Ltd 2015-02-03 /pmc/articles/PMC4335789/ /pubmed/25750731 http://dx.doi.org/10.12703/P7-13 Text en © 2015 Faculty of 1000 Ltd http://creativecommons.org/licenses/by-nc/3.0/legalcode All F1000Prime Reports articles are distributed under the terms of the Creative Commons Attribution-Non Commercial License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Brown, Kristin K.
Toker, Alex
The phosphoinositide 3-kinase pathway and therapy resistance in cancer
title The phosphoinositide 3-kinase pathway and therapy resistance in cancer
title_full The phosphoinositide 3-kinase pathway and therapy resistance in cancer
title_fullStr The phosphoinositide 3-kinase pathway and therapy resistance in cancer
title_full_unstemmed The phosphoinositide 3-kinase pathway and therapy resistance in cancer
title_short The phosphoinositide 3-kinase pathway and therapy resistance in cancer
title_sort phosphoinositide 3-kinase pathway and therapy resistance in cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335789/
https://www.ncbi.nlm.nih.gov/pubmed/25750731
http://dx.doi.org/10.12703/P7-13
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