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Lambert-Eaton syndrome IgG inhibits transmitter release via P/Q Ca(2+) channels

OBJECTIVE: To determine whether immunoglobulin G (IgG) from patients with Lambert-Eaton myasthenic syndrome (LEMS) decreases action potential–evoked synaptic vesicle exocytosis, and whether the effect is mediated by P/Q-type voltage-gated calcium channels (VGCCs). METHODS: IgG was obtained from 4 pa...

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Detalles Bibliográficos
Autores principales:	Spillane, Jennifer, Ermolyuk, Yaroslav, Cano-Jaimez, Marife, Lang, Bethan, Vincent, Angela, Volynski, Kirill E., Kullmann, Dimitri M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335987/ https://www.ncbi.nlm.nih.gov/pubmed/25589670 http://dx.doi.org/10.1212/WNL.0000000000001225

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