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Global Analysis Reveals Families of Chemical Motifs Enriched for hERG Inhibitors
Promiscuous inhibition of the human ether-à-go-go-related gene (hERG) potassium channel by drugs poses a major risk for life threatening arrhythmia and costly drug withdrawals. Current knowledge of this phenomenon is derived from a limited number of known drugs and tool compounds. However, in a dive...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4336329/ https://www.ncbi.nlm.nih.gov/pubmed/25700001 http://dx.doi.org/10.1371/journal.pone.0118324 |