Discovery of Desketoraloxifene Analogues as Inhibitors of Mammalian, Pseudomonas aeruginosa, and NAPE Phospholipase D Enzymes

[Image: see text] Phospholipase D (PLD) hydrolyses cellular lipids to produce the important lipid second messenger phosphatidic acid. A PLD enzyme expressed by Pseudomonas aeruginosa (PldA) has been shown to be important in bacterial infection, and NAPE-PLD has emerged as being key in the synthesis...

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Detalles Bibliográficos
Autores principales: Scott, Sarah A., Spencer, Cierra T., O’Reilly, Matthew C., Brown, Kyle A., Lavieri, Robert R., Cho, Chul-Hee, Jung, Dai-Il, Larock, Richard C., Brown, H. Alex, Lindsley, Craig W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4336625/
https://www.ncbi.nlm.nih.gov/pubmed/25384256
http://dx.doi.org/10.1021/cb500828m

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