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Probing Interactions between Lysine Residues in Histone Tails and Nucleosomal DNA via Product and Kinetic Analysis
[Image: see text] The histone proteins in nucleosome core particles are known to catalyze DNA cleavage at abasic and oxidized abasic sites, which are produced by antitumor antibiotics and as a consequence of other modalities of DNA damage. The lysine rich histone tails whose post-translational modif...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4336632/ https://www.ncbi.nlm.nih.gov/pubmed/25475712 http://dx.doi.org/10.1021/cb500737y |