Apoptotic Index and Proliferative Index in Premalignant and Malignant Squamous Cell Lesions of the Oral Cavity

BACKGROUND: Oral squamous cell lesions are most commonly diagnosed lesions in India. Both premalignant and malignant lesions are frequently encountered. In this study, we evaluated the role and significance of apoptotic indices (AI) and proliferative indices (PI) in premalignant and malignant squamo...

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Autores principales: Viswanathan, Vidya, Juluri, Ravichandra, Goel, Seema, Madan, Jyotsna, Mitra, Subir K, Gopalakrishnan, Dharmarajan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dentmedpub Research and Printing Co 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4336659/
https://www.ncbi.nlm.nih.gov/pubmed/25709366
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author Viswanathan, Vidya
Juluri, Ravichandra
Goel, Seema
Madan, Jyotsna
Mitra, Subir K
Gopalakrishnan, Dharmarajan
author_facet Viswanathan, Vidya
Juluri, Ravichandra
Goel, Seema
Madan, Jyotsna
Mitra, Subir K
Gopalakrishnan, Dharmarajan
author_sort Viswanathan, Vidya
collection PubMed
description BACKGROUND: Oral squamous cell lesions are most commonly diagnosed lesions in India. Both premalignant and malignant lesions are frequently encountered. In this study, we evaluated the role and significance of apoptotic indices (AI) and proliferative indices (PI) in premalignant and malignant squamous cell lesions of the oral cavity. MATERIALS AND METHODS: A total of 62 histologically proven cases of premalignant and malignant oral squamous cell lesions were analyzed. The biopsies were stained with hematoxylin and eosin and also with monoclonal antibody Ki-67. AI and PI were assessed using a light microscope. RESULTS: AI was found to increase gradually from normal to dysplasia to carcinoma. The highest AI was seen in well-differentiated squamous cell carcinomas (SCCs). PI also was found to increase significantly from normal to dysplasia to carcinoma. The highest PI was seen in poorly differentiated SCC. CONCLUSION: AI in conjunction with the PI offers an accurate idea as to the nature and course of the lesion and may help to plan timely surgical intervention that results in better clinical prognosis and outcome.
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spelling pubmed-43366592015-03-01 Apoptotic Index and Proliferative Index in Premalignant and Malignant Squamous Cell Lesions of the Oral Cavity Viswanathan, Vidya Juluri, Ravichandra Goel, Seema Madan, Jyotsna Mitra, Subir K Gopalakrishnan, Dharmarajan J Int Oral Health Original Research BACKGROUND: Oral squamous cell lesions are most commonly diagnosed lesions in India. Both premalignant and malignant lesions are frequently encountered. In this study, we evaluated the role and significance of apoptotic indices (AI) and proliferative indices (PI) in premalignant and malignant squamous cell lesions of the oral cavity. MATERIALS AND METHODS: A total of 62 histologically proven cases of premalignant and malignant oral squamous cell lesions were analyzed. The biopsies were stained with hematoxylin and eosin and also with monoclonal antibody Ki-67. AI and PI were assessed using a light microscope. RESULTS: AI was found to increase gradually from normal to dysplasia to carcinoma. The highest AI was seen in well-differentiated squamous cell carcinomas (SCCs). PI also was found to increase significantly from normal to dysplasia to carcinoma. The highest PI was seen in poorly differentiated SCC. CONCLUSION: AI in conjunction with the PI offers an accurate idea as to the nature and course of the lesion and may help to plan timely surgical intervention that results in better clinical prognosis and outcome. Dentmedpub Research and Printing Co 2015-01 /pmc/articles/PMC4336659/ /pubmed/25709366 Text en Copyright: © Journal of International Oral Health http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Viswanathan, Vidya
Juluri, Ravichandra
Goel, Seema
Madan, Jyotsna
Mitra, Subir K
Gopalakrishnan, Dharmarajan
Apoptotic Index and Proliferative Index in Premalignant and Malignant Squamous Cell Lesions of the Oral Cavity
title Apoptotic Index and Proliferative Index in Premalignant and Malignant Squamous Cell Lesions of the Oral Cavity
title_full Apoptotic Index and Proliferative Index in Premalignant and Malignant Squamous Cell Lesions of the Oral Cavity
title_fullStr Apoptotic Index and Proliferative Index in Premalignant and Malignant Squamous Cell Lesions of the Oral Cavity
title_full_unstemmed Apoptotic Index and Proliferative Index in Premalignant and Malignant Squamous Cell Lesions of the Oral Cavity
title_short Apoptotic Index and Proliferative Index in Premalignant and Malignant Squamous Cell Lesions of the Oral Cavity
title_sort apoptotic index and proliferative index in premalignant and malignant squamous cell lesions of the oral cavity
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4336659/
https://www.ncbi.nlm.nih.gov/pubmed/25709366
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