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Circadian variation in plasma 5-fluorouracil concentrations during a 24 hour constant-rate infusion

BACKGROUND: Varying the rate of continuous intravenous infusions of 5-fluorouracil (5FU) chemotherapy over a 24-hour period has been reported to improve patient outcomes. It has been hypothesized that circadian variation in drug disposition is a contributing factor. We analyzed 5-FU concentrations d...

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Detalles Bibliográficos
Autores principales:	Fleming, Gini F, Schumm, Philip, Friberg, Greg, Ratain, Mark J, Njiaju, Uchenna O, Schilsky, Richard L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4336691/ https://www.ncbi.nlm.nih.gov/pubmed/25885822 http://dx.doi.org/10.1186/s12885-015-1075-6

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