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Multicentric Castleman's Disease in a Child Revealed by Chronic Diarrhea

Multicentric Castleman's disease is a rare benign and unexplained lymphoproliferative disorder that is extremely uncommon in children. It presents with fever, systemic symptoms, generalized lymphadenopathy, and laboratory markers of inflammation. Its treatment is not standardized and its progno...

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Autores principales: Benmiloud, Sarra, Chaouki, Sana, Atmani, Samir, Hida, Moustapha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337035/
https://www.ncbi.nlm.nih.gov/pubmed/25737793
http://dx.doi.org/10.1155/2015/689206
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author Benmiloud, Sarra
Chaouki, Sana
Atmani, Samir
Hida, Moustapha
author_facet Benmiloud, Sarra
Chaouki, Sana
Atmani, Samir
Hida, Moustapha
author_sort Benmiloud, Sarra
collection PubMed
description Multicentric Castleman's disease is a rare benign and unexplained lymphoproliferative disorder that is extremely uncommon in children. It presents with fever, systemic symptoms, generalized lymphadenopathy, and laboratory markers of inflammation. Its treatment is not standardized and its prognosis is poor. We report a novel case of multicentric Castleman's disease in a 13-year-old girl who had presented with chronic diarrhea as the only initial presenting symptom. The diagnosis of celiac or inflammatory bowel diseases was suspected, but two and a half years later, the diagnosis of multicentric Castleman's disease was brought following the appearance of abdominal mass whose biopsy revealed Castleman's disease in the plasma cell form. The outcome was favorable after treatment by corticosteroid, chemotherapy, and surgery. The occurrence of diarrhea as the initial symptom of multicentric Castleman's disease without lymph node involvement is very rare. This case report underlines the diagnostic difficulties and the long interval between onset and diagnosis when diarrhea occurs first.
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spelling pubmed-43370352015-03-03 Multicentric Castleman's Disease in a Child Revealed by Chronic Diarrhea Benmiloud, Sarra Chaouki, Sana Atmani, Samir Hida, Moustapha Case Rep Pediatr Case Report Multicentric Castleman's disease is a rare benign and unexplained lymphoproliferative disorder that is extremely uncommon in children. It presents with fever, systemic symptoms, generalized lymphadenopathy, and laboratory markers of inflammation. Its treatment is not standardized and its prognosis is poor. We report a novel case of multicentric Castleman's disease in a 13-year-old girl who had presented with chronic diarrhea as the only initial presenting symptom. The diagnosis of celiac or inflammatory bowel diseases was suspected, but two and a half years later, the diagnosis of multicentric Castleman's disease was brought following the appearance of abdominal mass whose biopsy revealed Castleman's disease in the plasma cell form. The outcome was favorable after treatment by corticosteroid, chemotherapy, and surgery. The occurrence of diarrhea as the initial symptom of multicentric Castleman's disease without lymph node involvement is very rare. This case report underlines the diagnostic difficulties and the long interval between onset and diagnosis when diarrhea occurs first. Hindawi Publishing Corporation 2015 2015-02-09 /pmc/articles/PMC4337035/ /pubmed/25737793 http://dx.doi.org/10.1155/2015/689206 Text en Copyright © 2015 Sarra Benmiloud et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Benmiloud, Sarra
Chaouki, Sana
Atmani, Samir
Hida, Moustapha
Multicentric Castleman's Disease in a Child Revealed by Chronic Diarrhea
title Multicentric Castleman's Disease in a Child Revealed by Chronic Diarrhea
title_full Multicentric Castleman's Disease in a Child Revealed by Chronic Diarrhea
title_fullStr Multicentric Castleman's Disease in a Child Revealed by Chronic Diarrhea
title_full_unstemmed Multicentric Castleman's Disease in a Child Revealed by Chronic Diarrhea
title_short Multicentric Castleman's Disease in a Child Revealed by Chronic Diarrhea
title_sort multicentric castleman's disease in a child revealed by chronic diarrhea
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337035/
https://www.ncbi.nlm.nih.gov/pubmed/25737793
http://dx.doi.org/10.1155/2015/689206
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