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The Prevalence of Autoantibodies in Complex Regional Pain Syndrome Type I

Autoimmunity has been suggested as one of the pathophysiologic mechanisms that may underlie complex regional pain syndrome (CRPS). Screening for antinuclear antibodies (ANA) is one of the diagnostic tests, which is usually performed if a person is suspected to have a systemic autoimmune disease. Ant...

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Autores principales: Dirckx, Maaike, Schreurs, Marco W. J., de Mos, Marissa, Stronks, Dirk L., Huygen, Frank J. P. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337272/
https://www.ncbi.nlm.nih.gov/pubmed/25741131
http://dx.doi.org/10.1155/2015/718201
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author Dirckx, Maaike
Schreurs, Marco W. J.
de Mos, Marissa
Stronks, Dirk L.
Huygen, Frank J. P. M.
author_facet Dirckx, Maaike
Schreurs, Marco W. J.
de Mos, Marissa
Stronks, Dirk L.
Huygen, Frank J. P. M.
author_sort Dirckx, Maaike
collection PubMed
description Autoimmunity has been suggested as one of the pathophysiologic mechanisms that may underlie complex regional pain syndrome (CRPS). Screening for antinuclear antibodies (ANA) is one of the diagnostic tests, which is usually performed if a person is suspected to have a systemic autoimmune disease. Antineuronal antibodies are autoantibodies directed against antigens in the central and/or peripheral nervous system. The aim of this study was to compare the prevalence of these antibodies in CRPS patients with the normal values of those antibodies in the healthy population. Twenty seven (33%) of the 82 CRPS patients of whom serum was available showed a positive ANA test. This prevalence is significantly higher than in the general population. Six patients (7.3%) showed a positive result for typical antineuronal antibodies. This proportion, however, does not deviate from that in the general population. Our findings suggest that autoantibodies may be associated with the pathophysiology of CRPS, at least in a subset of patients. Further research is needed into defining this subset and into the role of autoantibodies in the pathogenesis of CRPS.
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spelling pubmed-43372722015-03-04 The Prevalence of Autoantibodies in Complex Regional Pain Syndrome Type I Dirckx, Maaike Schreurs, Marco W. J. de Mos, Marissa Stronks, Dirk L. Huygen, Frank J. P. M. Mediators Inflamm Research Article Autoimmunity has been suggested as one of the pathophysiologic mechanisms that may underlie complex regional pain syndrome (CRPS). Screening for antinuclear antibodies (ANA) is one of the diagnostic tests, which is usually performed if a person is suspected to have a systemic autoimmune disease. Antineuronal antibodies are autoantibodies directed against antigens in the central and/or peripheral nervous system. The aim of this study was to compare the prevalence of these antibodies in CRPS patients with the normal values of those antibodies in the healthy population. Twenty seven (33%) of the 82 CRPS patients of whom serum was available showed a positive ANA test. This prevalence is significantly higher than in the general population. Six patients (7.3%) showed a positive result for typical antineuronal antibodies. This proportion, however, does not deviate from that in the general population. Our findings suggest that autoantibodies may be associated with the pathophysiology of CRPS, at least in a subset of patients. Further research is needed into defining this subset and into the role of autoantibodies in the pathogenesis of CRPS. Hindawi Publishing Corporation 2015 2015-02-08 /pmc/articles/PMC4337272/ /pubmed/25741131 http://dx.doi.org/10.1155/2015/718201 Text en Copyright © 2015 Maaike Dirckx et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Dirckx, Maaike
Schreurs, Marco W. J.
de Mos, Marissa
Stronks, Dirk L.
Huygen, Frank J. P. M.
The Prevalence of Autoantibodies in Complex Regional Pain Syndrome Type I
title The Prevalence of Autoantibodies in Complex Regional Pain Syndrome Type I
title_full The Prevalence of Autoantibodies in Complex Regional Pain Syndrome Type I
title_fullStr The Prevalence of Autoantibodies in Complex Regional Pain Syndrome Type I
title_full_unstemmed The Prevalence of Autoantibodies in Complex Regional Pain Syndrome Type I
title_short The Prevalence of Autoantibodies in Complex Regional Pain Syndrome Type I
title_sort prevalence of autoantibodies in complex regional pain syndrome type i
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337272/
https://www.ncbi.nlm.nih.gov/pubmed/25741131
http://dx.doi.org/10.1155/2015/718201
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