The therapeutic effects of bone marrow mesenchymal stem cells after optic nerve damage in the adult rat

Optic nerve trauma is a common occurrence that results in irreversible blindness. Currently, no effective strategies are known to prevent optic nerve degeneration. We assessed the therapeutic effects of bone marrow mesenchymal stem cells (BMSCs) after optic nerve crush in the adult rat. Our results...

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Detalles Bibliográficos
Autores principales: Tan, HaiBo, Kang, Xin, Lu, ShiHeng, Liu, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337419/
https://www.ncbi.nlm.nih.gov/pubmed/25733825
http://dx.doi.org/10.2147/CIA.S75319
Descripción
Sumario:Optic nerve trauma is a common occurrence that results in irreversible blindness. Currently, no effective strategies are known to prevent optic nerve degeneration. We assessed the therapeutic effects of bone marrow mesenchymal stem cells (BMSCs) after optic nerve crush in the adult rat. Our results showed that BMSCs significantly promoted the regeneration of injured axons compared with phosphate buffered saline alone. Therefore, BMSC transplantation may be effective for the treatment of central nervous system disorders.

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