The therapeutic effects of bone marrow mesenchymal stem cells after optic nerve damage in the adult rat

Optic nerve trauma is a common occurrence that results in irreversible blindness. Currently, no effective strategies are known to prevent optic nerve degeneration. We assessed the therapeutic effects of bone marrow mesenchymal stem cells (BMSCs) after optic nerve crush in the adult rat. Our results...

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Detalles Bibliográficos
Autores principales: Tan, HaiBo, Kang, Xin, Lu, ShiHeng, Liu, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337419/
https://www.ncbi.nlm.nih.gov/pubmed/25733825
http://dx.doi.org/10.2147/CIA.S75319
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author Tan, HaiBo
Kang, Xin
Lu, ShiHeng
Liu, Lin
author_facet Tan, HaiBo
Kang, Xin
Lu, ShiHeng
Liu, Lin
author_sort Tan, HaiBo
collection PubMed
description Optic nerve trauma is a common occurrence that results in irreversible blindness. Currently, no effective strategies are known to prevent optic nerve degeneration. We assessed the therapeutic effects of bone marrow mesenchymal stem cells (BMSCs) after optic nerve crush in the adult rat. Our results showed that BMSCs significantly promoted the regeneration of injured axons compared with phosphate buffered saline alone. Therefore, BMSC transplantation may be effective for the treatment of central nervous system disorders.
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spelling pubmed-43374192015-03-02 The therapeutic effects of bone marrow mesenchymal stem cells after optic nerve damage in the adult rat Tan, HaiBo Kang, Xin Lu, ShiHeng Liu, Lin Clin Interv Aging Short Report Optic nerve trauma is a common occurrence that results in irreversible blindness. Currently, no effective strategies are known to prevent optic nerve degeneration. We assessed the therapeutic effects of bone marrow mesenchymal stem cells (BMSCs) after optic nerve crush in the adult rat. Our results showed that BMSCs significantly promoted the regeneration of injured axons compared with phosphate buffered saline alone. Therefore, BMSC transplantation may be effective for the treatment of central nervous system disorders. Dove Medical Press 2015-02-16 /pmc/articles/PMC4337419/ /pubmed/25733825 http://dx.doi.org/10.2147/CIA.S75319 Text en © 2015 Tan et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Short Report
Tan, HaiBo
Kang, Xin
Lu, ShiHeng
Liu, Lin
The therapeutic effects of bone marrow mesenchymal stem cells after optic nerve damage in the adult rat
title The therapeutic effects of bone marrow mesenchymal stem cells after optic nerve damage in the adult rat
title_full The therapeutic effects of bone marrow mesenchymal stem cells after optic nerve damage in the adult rat
title_fullStr The therapeutic effects of bone marrow mesenchymal stem cells after optic nerve damage in the adult rat
title_full_unstemmed The therapeutic effects of bone marrow mesenchymal stem cells after optic nerve damage in the adult rat
title_short The therapeutic effects of bone marrow mesenchymal stem cells after optic nerve damage in the adult rat
title_sort therapeutic effects of bone marrow mesenchymal stem cells after optic nerve damage in the adult rat
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337419/
https://www.ncbi.nlm.nih.gov/pubmed/25733825
http://dx.doi.org/10.2147/CIA.S75319
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