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Expression of Functional Sphingosine-1 Phosphate Receptor-1 Is Reduced by B Cell Receptor Signaling and Increased by Inhibition of PI3 Kinase δ but Not SYK or BTK in Chronic Lymphocytic Leukemia Cells

BCR signaling pathway inhibitors such as ibrutinib, idelalisib, and fostamatinib (respective inhibitors of Bruton’s tyrosine kinase, PI3Kδ, and spleen tyrosine kinase) represent a significant therapeutic advance in B cell malignancies, including chronic lymphocytic leukemia (CLL). These drugs are di...

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Detalles Bibliográficos
Autores principales:	Till, Kathleen J., Pettitt, Andrew R., Slupsky, Joseph R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AAI 2015
Materias:	Tumor Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337486/ https://www.ncbi.nlm.nih.gov/pubmed/25632006 http://dx.doi.org/10.4049/jimmunol.1402304

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